机构：[a]Intensive Care Unit,The First Affiliated Hospital, Jinan University, Guangzhou,[b]Department of Rehabilitation, Dongpu Branch,The First Affiliated Hospital, Jinan University, Guangzhou,[c]Department of Orthopedics, The First Affiliated Hospital, Jinan University, Guangzhou,[d]Department of Traumatology and Plastic Surgery, The Affiliated Jiangmen Traditional Chinese Medicine Hospital of Jinan University, Jiangmen[e]College of Chinese Language and Culture, Jinan University, Guangzhou, Guangdong, People’s Republic of China
LINC00673 is an oncogene that plays a key role in various cancer types. However, the role of LINC00673 in glioma remains unclear. In this study, we examined its expression in glioma cells by quantitative real-time PCR and found higher expression of LINC00673 in glioma cells compared with that in normal human astrocytes. Furthermore, LINC00673 silencing inhibited the migration and invasion of U87MG and U118MG cells, phosphoinositide 3-kinase (PI3K) expression, and AKT phosphorylation. Moreover, activation of the PI3K/AKT signaling pathway by insulin-like Growth factor-1 abolished the inhibitory effect of LINC00673 silencing on the migration and invasion of U87MG and U118MG cells. In conclusion, LINC00673 silencing inhibits glioma cell migration and invasion by suppressing the PI3K/AKT signaling pathway, and it is a potential therapeutic target for the treatment of metastatic glioma.
基金：
This work was supported by grants from the Key Program
of Traditional Chinese Medicine of Guangdong Province
(No. 20173018) and Science and Technology Program of
Jiangmen City of China (Nos 2015751 and 2017A2004).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区神经科学
最新[2025]版：
大类|4 区医学
小类|4 区神经科学
第一作者：
第一作者机构：[a]Intensive Care Unit,The First Affiliated Hospital, Jinan University, Guangzhou,
共同第一作者：
通讯作者：
通讯机构：[e]College of Chinese Language and Culture, Jinan University, Guangzhou, Guangdong, People’s Republic of China[*1]College of Chinese Language and Culture, Jinan University, No. 377, Shougouling Road, Tianhe District, Guangzhou 510610, People’s Republic of China
推荐引用方式(GB/T 7714)：
Feng Zhang,Yuen Huang,Bata Wang,et al.LINC00673 silencing inhibits cell migration and invasion by suppressing PI3K/AKT signaling in glioma.[J].Neuroreport.2018,29(9):718-722.doi:10.1097/WNR.0000000000001022.
APA：
Feng Zhang,Yuen Huang,Bata Wang,Cheng Zhong,Xiaofeng Liu&Shanshan Ding.(2018).LINC00673 silencing inhibits cell migration and invasion by suppressing PI3K/AKT signaling in glioma..Neuroreport,29,(9)
MLA：
Feng Zhang,et al."LINC00673 silencing inhibits cell migration and invasion by suppressing PI3K/AKT signaling in glioma.".Neuroreport 29..9(2018):718-722
