机构：[1]Department of Infection Control, Guangzhou Hospital of Traditional Chinese Medicine, Guangzhou,Guangdong 510130[2]Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou MedicalUniversity, Guangzhou 510120[3]Department of Clinical Laboratory, GuangzhouHospital of Traditional Chinese Medicine, Guangzhou, Guangdong 510130[4]Department of Spleen and Gastroenterology, GuangzhouHospital of Traditional Chinese Medicine, Guangzhou, Guangdong 510130[5]Department of Laboratory Medicine,Nanhai Hospital, Southern Medical University, Foshan, Guangdong, 528244, P.R. China
Colorectal cancer (CRC) is one of the most common malignancies worldwide. Collapsin response mediator protein 5 (CRMP5) belongs to a family of five cytosolic proteins that serve a major role in neural development. CRMP5 has been identified as a biomarker of numerous cancer types, including lung cancer and glioblastoma. However, the role of CRMP5 in CRC remains unclear. In the present study, CRMP5 was characterized as a novel biomarker of poor survival in CRC. CRMP5-overexpression in CRC cells promoted cell proliferation and migration while CPMP5-knockdown decreased cell growth and migration. A novel mechanism was uncovered, by which CRMP5 regulates MAPK signaling to drive CRC cell proliferation and development. Furthermore, CRMP5-overexpression induced chemotherapy resistance and tumor recurrence in CRC. Taken together, these results demonstrated the important role of CRMP5 in the development and proliferation of CRC cells and suggested that CRMP5 may be a novel therapeutic target for CRC.
基金：
National Natural Science Foundation of China (grant no. 81503424),
Guangzhou Science and Technology Innovation Commission
(grant no. 201704020171), the Medical Key Discipline Planning
Project of Foshan City (grant no. FSZDZK135045), and the
Science and Technology Planning Project of Guangdong
Province (grant no. 2019B020208009).
第一作者机构：[1]Department of Infection Control, Guangzhou Hospital of Traditional Chinese Medicine, Guangzhou,Guangdong 510130
通讯作者：
通讯机构：[5]Department of Laboratory Medicine,Nanhai Hospital, Southern Medical University, Foshan, Guangdong, 528244, P.R. China[*1]Department of Laboratory Medicine, Nanhai Hospital, Southern Medical University, 28 Liguan Road, Foshan, Guangdong 528244, P.R. China
推荐引用方式(GB/T 7714)：
Qiu Fanghua,Yu Lin,Liu Daoli,et al.CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK-dependent signaling[J].ONCOLOGY LETTERS.2021,22(5):doi:10.3892/ol.2021.13008.
APA：
Qiu, Fanghua,Yu, Lin,Liu, Daoli,Wu, Yujin&Qiu, Feng.(2021).CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK-dependent signaling.ONCOLOGY LETTERS,22,(5)
MLA：
Qiu, Fanghua,et al."CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK-dependent signaling".ONCOLOGY LETTERS 22..5(2021)
