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Targeted therapy with anlotinib for a leptomeningeal spread recurrent glioblastoma patient.

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机构: [1]he Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province Hospital of Chinese Medical, Guangzhou, China [2]Department of Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China [3]Department of Oncology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China [4]International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden
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关键词: Glioblastoma Anlotinib Leptomeningeal spread

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Glioblastoma (GBM) is the most common and the most aggressive primary malignant brain tumor in adults. Although tumor recurrence is inevitable, leptomeningeal spread is relatively rare. We describe a case of leptomeningeal spread recurrent GBM treated with anlotinib in this report. When the recurrent GBM patient had leptomeningeal spread was administered anlotinib 10mg p.o. once every day and added oral temozolomide chemotherapy 100mg/m2 (days 1-7, days 15-21, 28-day cycle) after 3 months. The patient's overall survival time was more than 5 months and developed oral ulcer and acute cerebral infarction during his oral administration of anlotinib. This patient showed a favorable clinic outcome for treatment of leptomeningeal spread recurrent GBM with anlotinib and didn't show serious side effects.Copyright © 2021 Elsevier B.V. All rights reserved.

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大类 | 3 区 医学
小类 | 4 区 神经科学
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第一作者机构: [1]he Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province Hospital of Chinese Medical, Guangzhou, China
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