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Biodegradable mesoporous manganese carbonate nanocomposites for LED light-driven cancer therapy via enhancing photodynamic therapy and attenuating survivin expression.

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机构： [1]The State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques, Analytical and Testing Center, South China University of Technology, Guangzhou 510640, Guangdong, China [2]Guangdong Key Lab of Orthopedic Technology and Implant, General Hospital of Southern Theater Command of PLA, The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China [3]The Fifth Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510095, China

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关键词： Triple negative breast cancer Mesoporous MnCO3 nanocubes LED light responsive O2 and CO2 release Reactive oxygen species

摘要：

Triple-negative breast cancer (TNBC) is one of the most daunting diseases, low toxicity and efficient approaches are in urgent demand. Herein, we developed degradable mesoporous manganese carbonate nanocubes (MnCO3 NCs), incorporated with survivin shRNA-expressing plasmid DNA (iSur-pDNA) and riboflavin (Rf), namely MRp NCs, for synergistic TNBC therapy. The MnCO3, itself, could generate O2 and CO2 under H2O2 and thus relieve the hypoxia and acidic tumor microenvironment (TME). Furthermore, the MnCO3 NCs exhibited high Rf loading capacity and iSur-pDNA delivery ability after polyethyleneimine modification. Specifically, MRp NCs decompose in TME, meanwhile they deprived the endogenous expression of survivin gene and significantly amplified the generation of reactive oxygen species after exposure to LED light, resulting in serious tumor destruction. The multifunctional MRp NCs with LED light-driven characters are able to provide a high efficiency, low toxicity and promising strategy for TNBC therapy.© 2021. The Author(s).

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出版当年[2020]版：

大类 | 2 区工程技术

小类 | 2 区生物工程与应用微生物 3 区纳米科技

最新[2025]版：

大类 | 1 区

生物学

小类 | 1 区生物工程与应用微生物 2 区纳米科技

第一作者：

第一作者机构： [1]The State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques, Analytical and Testing Center, South China University of Technology, Guangzhou 510640, Guangdong, China

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Biodegradable mesoporous manganese carbonate nanocomposites for LED light-driven cancer therapy via enhancing photodynamic therapy and attenuating survivin expression.

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