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Role of gut microbiota in functional constipation.

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收录情况： ◇ SCIE

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机构： [1]Digestive Disease Center, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University,Beijing, P. R. China [2]Department of Colorectal Surgery, Guangdong Institute of Gastroenterology,Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital ofSun Yat-sen University, Guangzhou, Guangdong, P. R. China

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关键词： gut microbiota functional constipation bile acids SCFA serotonin traditional Chinese medicine

摘要：

Functional constipation (FC) is common, yet the etiology is not clear. Accumulating evidence suggests an association between FC and abnormal gut microbiota. The relationship between the gut microbiota and the gut transit is likely bidirectional. This review summarizes the current evidence regarding the impact of gut microbiota on the pathogenesis of FC. By modulating the colonic motility, secretion, and absorption, gut microbiota may contribute to the development of FC through microbial metabolic activities involving bile acids, short-chain fatty acids, 5-hydroxytryptamine, and methane. In support of the key roles of the gut microbiota in FC, treatment with probiotics, prebiotics, synbiotics, and traditional Chinese medicine often result in compositional and functional changes in the gut microbiota. Further studies on the pathogenesis of FC and the therapeutic mechanism of microecological agents will provide a knowledge base for better management of FC.© The Author(s) 2021. Published by Oxford University Press and Sixth Affiliated Hospital of Sun Yat-sen University.

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出版当年[2020]版：

大类 | 3 区医学

小类 | 4 区胃肠肝病学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区胃肠肝病学

JCR分区：

出版当年[2019]版：

Q3 GASTROENTEROLOGY & HEPATOLOGY

最新[2023]版：

Q2 GASTROENTEROLOGY & HEPATOLOGY

影响因子： 3.8 最新[2023版] 3.8 最新五年平均 2.96 出版当年[2019版] 0 出版当年五年平均 2.194 出版前一年[2018版] 3.651 出版后一年[2020版]

第一作者：

第一作者机构： [1]Digestive Disease Center, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University,Beijing, P. R. China

通讯作者：

通讯机构： [1]Digestive Disease Center, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University,Beijing, P. R. China [2]Department of Colorectal Surgery, Guangdong Institute of Gastroenterology,Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital ofSun Yat-sen University, Guangzhou, Guangdong, P. R. China [*1]Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong 510655, P. R. China [*2]Digestive Disease Center, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, 23 Meishuguan Back Street, Beijing 100010, P. R. China

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