机构：[1]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Clinical Medicial College, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China[2]Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, Guangzhou 510006, PR China[3]Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, PR China[4]Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou 510632, PR China
Five novel triterpenoid saponins, hovenidulciosides C-G (1-5), and one known saponin hovenidulcioside A1 (6) were isolated from the seeds of Hovenia dulcis Thunb. The structures of 1-5 were determined through spectroscopic methods such as HR-ESI-MS, 2D-NMR (H-1-H-1 COSY, HSQC, HMBC, ROESY and TOCSY), UV and IR and chemical methods. There were amino acetylated substituent in the sugar resident of hovenidulciosides F-G, which were firstly reported from this genus. Compound 1 supressed ARE-luciferase activity in MDA-MB-231 cells and inhib-ited the Nrf2 protein levels in A549 cells. (C) 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.
基金：
National Natural Science
Foundation of China (Nos. 81703379 and U1801287); the
National Key Research and Development Program of China
(No. 2018YFC1707900); (Nos. 2017B030314166,
2017BT01Y036 and 2020B1111110004); The Special Foundation
of Guangzhou Key Laboratory (No. 202002010004);
Science and Technology Planning Project of Guangzhou
(No. 202102021213).
第一作者机构：[1]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Clinical Medicial College, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China[2]Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, Guangzhou 510006, PR China
共同第一作者：
通讯作者：
通讯机构：[1]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Clinical Medicial College, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China[2]Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, Guangzhou 510006, PR China[4]Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou 510632, PR China[*1]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Clinical Medicial College, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
推荐引用方式(GB/T 7714)：
Cai Wanna,Xu Shengmei,Ma Ting,et al.Five novel triterpenoid saponins from Hovenia dulcis and their Nrf2 inhibitory activities[J].ARABIAN JOURNAL OF CHEMISTRY.2021,14(8):doi:10.1016/j.arabjc.2021.103292.
APA：
Cai, Wanna,Xu, Shengmei,Ma, Ting,Zhang, Xiaoqi,Liu, Bo&Xu, Fangfang.(2021).Five novel triterpenoid saponins from Hovenia dulcis and their Nrf2 inhibitory activities.ARABIAN JOURNAL OF CHEMISTRY,14,(8)
MLA：
Cai, Wanna,et al."Five novel triterpenoid saponins from Hovenia dulcis and their Nrf2 inhibitory activities".ARABIAN JOURNAL OF CHEMISTRY 14..8(2021)
