机构：[1]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Clinical Medicial College, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China[2]Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, Guangzhou 510006, PR China[3]Guangdong Institute for Drug Control, Guangzhou 510663, PR China[4]Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou 510632, PR China[5]Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China
Three novel bisflavonol derivatives, Hovenianins A-C, along with 12 known flavonoids were isolated and identified from the seeds of Hovenia dulcis Thunb. Their structures were established on the basis of spectroscopic methods (MS, UV, IR, 1D and 2D NMR) and electronic circular dichroism experiments. Hovenianin A (1) was the first dimer of flavonol linked dihydroflavonol via the B rings at C-2' and C-2'''positions to be found in nature. While Hovenianins BC (2-3) were a pair of diastereoisomeric bis-dihydroflavonols firstly reported in the Hovenia genus. The in vitro antiviral activity against respiratory syncytium virus (RSV) were evaluated by cytopathic effect (CPE) reduction assay. As a result, compounds 4, 5, and 10 displayed better antiviral effect against RSV A2 strains.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81703379, U1801287]; Science and Technology Planning Project of Guangdong Province [2017B030314166, 2018B020207008]; Special Funds for Inheriting and Developing the Traditional Chinese Medicine from TCM Bureau of Guangdong Province [20181121, 20191137, 20191142]; Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine [YN2016QJ05, YN2015MS03]; Key Project of High-level University Construction of Guangzhou University of Chinese Medicine [XK2018019]
第一作者机构：[1]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Clinical Medicial College, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China[2]Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, Guangzhou 510006, PR China
共同第一作者：
通讯作者：
通讯机构：[1]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Clinical Medicial College, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China[2]Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, Guangzhou 510006, PR China[5]Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China
推荐引用方式(GB/T 7714)：
Xu Fangfang,Gao Meihua,Li Hua,et al.Three new bisflavonols from the seeds of Hovenia dulcis Thunb. and their anti-RSV activities[J].FITOTERAPIA.2020,143:doi:10.1016/j.fitote.2020.104587.
APA：
Xu, Fangfang,Gao, Meihua,Li, Hua,Han, Xiaodong,Zhang, Xiaoqi...&Liu, Bo.(2020).Three new bisflavonols from the seeds of Hovenia dulcis Thunb. and their anti-RSV activities.FITOTERAPIA,143,
MLA：
Xu, Fangfang,et al."Three new bisflavonols from the seeds of Hovenia dulcis Thunb. and their anti-RSV activities".FITOTERAPIA 143.(2020)
