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Chinese medicinal herbs for idiopathic membranous nephropathy in adults with nephrotic syndrome A systematic review of effectiveness and safety

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机构: [1]Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China [2]Department of Nephrology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China [3]The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China, [4]Guangzhou University of Chinese Medicine, Guangzhou, China [5]Second Outpatient Department, First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China [6]Department of Oncology, the Second People’s Hospital of Hunan Province, Changsha, China [7]School of Basic Medicine, Nanjing University of Chinese Medicine, Nanjing, China [8]State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangzhou, China.
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关键词: Chinese medicinal herbs membranous nephropathy meta-analysis nephrotic syndrome treatment

摘要:
To assess the benefits and harms of Chinese medicinal herbs formulae for the treatment of idiopathic membranous nephropathy in adult patients with primary nephrotic syndrome. Only randomized controlled trials were included. We searched the Cochrane Central Register of Controlled Trials database, PubMed, EMBASE, Chinese National Knowledge Internet, Chinese Biomedicine Database, and VIP. All studies were analyzed using the criteria of the Cochrane Handbook and were assessed in terms of quality and the risk of bias. Review Manager ver. 5.3.5 software was used for the data analysis, and GRADE profiler software was employed to evaluate quality. Two studies were included (n = 126 Chinese participants). We found that compared with against conventional treatment, one Chinese medicinal herbs formula plus conventional treatment reduced 24-hours urinary total protein (mean differences -3.16 g/24 h, 95% confidence intervals -4.03 to -2.29), and two Chinese medicinal herbs formulae increased serum albumin levels (mean differences 3.18 g/L, 95% confidence intervals 1.12 to 5.52; I-2 = 0%). Chinese medicinal herbs formulae may reduce 24-hours urinary total protein and increase serum levels of albumin. However, larger and multicenter studies with high methodological quality are still needed.

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出版当年[2020]版:
大类 | 4 区 医学
小类 | 4 区 医学:内科
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 医学:内科
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出版当年[2019]版:
Q3 MEDICINE, GENERAL & INTERNAL
最新[2023]版:
Q2 MEDICINE, GENERAL & INTERNAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者:
第一作者机构: [1]Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China [2]Department of Nephrology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China [3]The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China,
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通讯作者:
通讯机构: [4]Guangzhou University of Chinese Medicine, Guangzhou, China [5]Second Outpatient Department, First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China [*1]Guangzhou University of Chinese Medicine, No. 12 Jichang Road, Baiyun District, Guangzhou, 510405, China
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