机构:[1]Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China大德路总院肾内科大德路总院肾内科广东省中医院[2]Department of Nephrology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China大德路总院肾内科大德路总院肾内科广东省中医院[3]The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China,广东省中医院[4]Guangzhou University of Chinese Medicine, Guangzhou, China深圳市中医院深圳医学信息中心[5]Second Outpatient Department, First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China[6]Department of Oncology, the Second People’s Hospital of Hunan Province, Changsha, China[7]School of Basic Medicine, Nanjing University of Chinese Medicine, Nanjing, China[8]State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangzhou, China.
To assess the benefits and harms of Chinese medicinal herbs formulae for the treatment of idiopathic membranous nephropathy in adult patients with primary nephrotic syndrome. Only randomized controlled trials were included. We searched the Cochrane Central Register of Controlled Trials database, PubMed, EMBASE, Chinese National Knowledge Internet, Chinese Biomedicine Database, and VIP. All studies were analyzed using the criteria of the Cochrane Handbook and were assessed in terms of quality and the risk of bias. Review Manager ver. 5.3.5 software was used for the data analysis, and GRADE profiler software was employed to evaluate quality. Two studies were included (n = 126 Chinese participants). We found that compared with against conventional treatment, one Chinese medicinal herbs formula plus conventional treatment reduced 24-hours urinary total protein (mean differences -3.16 g/24 h, 95% confidence intervals -4.03 to -2.29), and two Chinese medicinal herbs formulae increased serum albumin levels (mean differences 3.18 g/L, 95% confidence intervals 1.12 to 5.52; I-2 = 0%). Chinese medicinal herbs formulae may reduce 24-hours urinary total protein and increase serum levels of albumin. However, larger and multicenter studies with high methodological quality are still needed.
基金:
National Natural Science Foundation of China (Grant No. 81873261).
第一作者机构:[1]Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China[2]Department of Nephrology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China[3]The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China,
共同第一作者:
通讯作者:
通讯机构:[4]Guangzhou University of Chinese Medicine, Guangzhou, China[5]Second Outpatient Department, First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China[*1]Guangzhou University of Chinese Medicine, No. 12 Jichang Road, Baiyun District, Guangzhou, 510405, China
推荐引用方式(GB/T 7714):
Liu Meifang,Yang Qianchun,Hua Qiaoli,et al.Chinese medicinal herbs for idiopathic membranous nephropathy in adults with nephrotic syndrome A systematic review of effectiveness and safety[J].MEDICINE.2021,100(50):doi:10.1097/MD.0000000000027953.
APA:
Liu, Meifang,Yang, Qianchun,Hua, Qiaoli,Liu, Jialing,He, Weifeng...&Liu, Xusheng.(2021).Chinese medicinal herbs for idiopathic membranous nephropathy in adults with nephrotic syndrome A systematic review of effectiveness and safety.MEDICINE,100,(50)
MLA:
Liu, Meifang,et al."Chinese medicinal herbs for idiopathic membranous nephropathy in adults with nephrotic syndrome A systematic review of effectiveness and safety".MEDICINE 100..50(2021)