机构：[1]Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China广东省中医院[2]Department of Immunology and Microbiology, Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, 200025, China
Melanoma is a life-threatening cancer with limited treatments. Retinoic acid-inducible gene I (RIG-I) is a cytosolic pattern recognition receptor (PRR) crucial to RNA virus sensing, interferon production, and tumor suppression. Quercetin, a natural flavonoid, has particularly therapeutic interests to prevent and treat cancer, for its pharmacological effects against oxidant, inflammation, and angiogenesis. Quercetin was investigated for its anti-melanoma activity and potential mechanisms in this study. We found that quercetin inhibited mouse melanoma growth in vivo, and suppressed proliferation and promoted apoptosis of both B16 and A375 cells in vitro. Quercetin upregulated IFN-alpha and IFN-beta expression through activating RIG-I promoter in B16 cells. The induction of IFN-alpha and IFN-beta, which could be severely impaired by silencing RIG-I induced interferon stimulated genes (ISGs). Moreover, RIG-I likely amplifies antitumor effects by activating signal transduction and activator of transcription 1 (STAT1) in the IFN-JAK-STAT pathway in an autocrine and paracrine manner. Our study provided novel insights regarding biological and anti-proliferative activities of quercetin against melanoma, and we identified RIG-I as a potential target in anti-tumor therapies.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81725018, 31570922, 81703118, 81803123]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|3 区医学：研究与实验3 区药学
最新[2025]版：
大类|2 区医学
小类|2 区医学：研究与实验2 区药学
JCR分区：
出版当年[2018]版：
Q1PHARMACOLOGY & PHARMACYQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[1]Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China[2]Department of Immunology and Microbiology, Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, 200025, China
通讯作者：
通讯机构：[1]Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China[2]Department of Immunology and Microbiology, Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, 200025, China[*1]Shanghai General Hospital/ Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine (SJTU-SM) 280 Chongqing South Road, 200025 Shanghai, China
推荐引用方式(GB/T 7714)：
Peng Danhong,Chen Linjiao,Sun Yang,et al.Melanoma suppression by quercein is correlated with RIG-I and type I interferon signaling[J].BIOMEDICINE & PHARMACOTHERAPY.2020,125:doi:10.1016/j.biopha.2020.109984.
APA：
Peng, Danhong,Chen, Linjiao,Sun, Yang,Sun, Libo,Yin, Qianqian...&Wang, Honglin.(2020).Melanoma suppression by quercein is correlated with RIG-I and type I interferon signaling.BIOMEDICINE & PHARMACOTHERAPY,125,
MLA：
Peng, Danhong,et al."Melanoma suppression by quercein is correlated with RIG-I and type I interferon signaling".BIOMEDICINE & PHARMACOTHERAPY 125.(2020)
