Comparison between spleen and liver stiffness measurements by sound touch elastography for diagnosing cirrhosis at different aminotransferase levels: a prospective multicenter study
机构：[1]Department of Ultrasound, Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, China中山大学附属第三医院[2]Department of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China[3]Department of Ultrasound, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, China[4]Department of Medical Ultrasonics, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China深圳市康宁医院深圳医学信息中心[5]Department of Ultrasound, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China[6]Department of Ultrasound, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China[7]Department of Ultrasound, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China[8]Department of Ultrasound, Mianyang Center Hospital, Mianyang, China[9]Department of Abdominal Ultrasound, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China[10]Department of Ultrasound, Ningbo Yinzhou No. 2 Hospital, Ningbo, China[11]Department of Ultrasound, Beijing Ditan Hospital, Capital Medical University, Beijing, China[12]Department of Ultrasound, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China[13]Department of Ultrasound, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China浙江大学医学院附属第一医院[14]Department of Ultrasound, The First Hospital of Lanzhou University, Lanzhou, China[15]Ultrasound Imaging Department, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China深圳市康宁医院深圳医学信息中心[16]Department of Ultrasound, Fuyang People’s Hospital, Fuyang, China[17]Department of Medical Ultrasonography, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[18]Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China[19]Ultrasonography, Shijiazhuang Fifth Hospital, Shijiazhuang, China[20]Department of Ultrasound, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China[21]Ultrasound Department, Third Medical Center of PLA General Hospital, Beijing, China[22]Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China[23]Department of Ultrasound, The Third Central Hospital of Tianjin, Tianjin, China[24]Department of Ultrasound, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China[25]Department of Ultrasound, Yichang Central People’s Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
Objectives To compare the performance of spleen stiffness measurement (SSM) and liver stiffness measurement (LSM) by sound touch elastography (STE) for the diagnosis of cirrhosis at different alanine aminotransferase (ALT) levels, and to compare the applicability and repeatability of SSM with LSM performed by STE, a new two-dimensional shear wave elastography technology. Methods This prospective multicenter study included 25 centers and recruited chronic hepatitis B (CHB) patients with liver biopsy between May 2018 and November 2019. All patients underwent LSM and SSM by STE. Success and reliability rates were calculated and compared. Intra-observer agreement was assessed using intraclass correlation coefficients (ICCs). Differences between areas under the receiver operating characteristic curves (AUCs) of LSMs and SSMs at different ALT levels were compared using the Delong test. Results Among 603 CHB patients, the success and reliability rates of SSM were 94.53% (570/603) and 85.74% (517/603), respectively, which were similar to those of LSM (p > 0.05), respectively. The ICC for intra-observer agreements of SSM was 0.964 (p < 0.001). In the total cohort, ALT <= 2 x upper limit of normal (ULN) group, and A0-1 group, the AUCs of SSMs were significantly lower than those of LSMs for the diagnosis of cirrhosis (p < 0.001). In the ALT > 2 x ULN group and A2-3 group, the AUC of SSM improved and was not significantly different from that of LSM (p = 0.342, p = 0.510, respectively). Conclusions SSM by STE achieved applicability and repeatability equivalent to those of LSM. SSM might be a good substitute to LSM in patients with high ALT levels.
基金：
This study has received funding from the National Natural
Science Foundation of China (No. 81827802).
第一作者机构：[1]Department of Ultrasound, Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Wei,Wang Jinfeng,Linghu Runze,et al.Comparison between spleen and liver stiffness measurements by sound touch elastography for diagnosing cirrhosis at different aminotransferase levels: a prospective multicenter study[J].EUROPEAN RADIOLOGY.2022,32(7):4980-4990.doi:10.1007/s00330-022-08569-x.
APA：
Zhang, Wei,Wang, Jinfeng,Linghu, Runze,Chen, Xiaoyan,Dong, Changfeng...&Liang, Ping.(2022).Comparison between spleen and liver stiffness measurements by sound touch elastography for diagnosing cirrhosis at different aminotransferase levels: a prospective multicenter study.EUROPEAN RADIOLOGY,32,(7)
MLA：
Zhang, Wei,et al."Comparison between spleen and liver stiffness measurements by sound touch elastography for diagnosing cirrhosis at different aminotransferase levels: a prospective multicenter study".EUROPEAN RADIOLOGY 32..7(2022):4980-4990
医学