机构：[1]Institute of Intervention Vessel, Shanghai 10th People’s Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai, People’s Republic of China[2]College of Traditional Chinese Medicine, North China University of Science and Technology, Tangshan, Hebei, People’s Republic of China[3]Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China[4]Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, Guangdong, People’s Republic of China[5]National Clinical Research Center for Interventional Medicine, Shanghai 10th People’s Hospital, Tongji University, Shanghai, People’s Republic of China
Snail (Sna) plays a pivotal role in epithelia-mesenchymal transition and cancer metastasis, yet its functions in normal tissue development remain elusive. Here, using Drosophila as a model organism, we identified Sna as an essential regulator of Hippo signalling-mediated cell proliferation and tissue growth. First, Sna is necessary and sufficient for impaired Hippo signalling-induced cell proliferation and tissue overgrowth. Second, Sna is necessary and sufficient for the expression of Hippo pathway target genes. Third, genetic epistasis data indicate Sna acts downstream of Yki in the Hippo signalling. Finally, Sna is physiologically required for tissue growth in normal development. Mechanistically, Yki activates the transcription of sna, whose protein product binds to Scalloped (Sd) and promotes Sd-dependent cell proliferation. Thus, this study uncovered a previously unknown physiological function of Sna in normal tissue development and revealed the underlying mechanism by which Sna modulates Hippo signalling-mediated cell proliferation and tissue growth.
基金：
This work is supported by the National Natural Science Foundation
of China (grant no. 31970536), Shanghai Committee of Science
and Technology (grant nos 09DZ2260100 and 19MC1910300) and the
Fundamental Research Funds for the Central Universities (grant no.
22120180549).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|2 区生物学
小类|3 区生化与分子生物学
最新[2025]版：
大类|2 区生物学
小类|3 区生化与分子生物学
第一作者：
第一作者机构：[1]Institute of Intervention Vessel, Shanghai 10th People’s Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Institute of Intervention Vessel, Shanghai 10th People’s Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai, People’s Republic of China[4]Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, Guangdong, People’s Republic of China[5]National Clinical Research Center for Interventional Medicine, Shanghai 10th People’s Hospital, Tongji University, Shanghai, People’s Republic of China
推荐引用方式(GB/T 7714)：
Ding Xiang,Li Zhuojie,Peng Kai,et al.Snail regulates Hippo signalling-mediated cell proliferation and tissue growth in Drosophila.[J].Open biology.2022,12(3):210357.doi:10.1098/rsob.210357.
APA：
Ding Xiang,Li Zhuojie,Peng Kai,Zou Rui,Wu Chenxi...&Xue Lei.(2022).Snail regulates Hippo signalling-mediated cell proliferation and tissue growth in Drosophila..Open biology,12,(3)
MLA：
Ding Xiang,et al."Snail regulates Hippo signalling-mediated cell proliferation and tissue growth in Drosophila.".Open biology 12..3(2022):210357
