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Conducting molybdenum sulfide/graphene oxide/polyvinyl alcohol nanocomposite hydrogel for repairing spinal cord injury.

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文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Chen Lingling[1] * ; Wang Wanshun[1,2] * ; Lin Zefeng[1] ; Lu Yao[3,4] ; Chen Hu[1,3] ; Li Binglin[1] ; Li Zhan[1] ; Xia Hong[1,3] ; Li Lihua[5] ; Zhang Tao[1,3] ;
机构： [1]Guangdong Key Lab of Orthopedic Technology and Implant Materials, Key Laboratory of Trauma & Tissue Repair of Tropical Area of PLA, Orthopedic Center, General Hospital of Southern Theater Command of PLA, Guangzhou 510010, Guangdong, China. [2]The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China. [3]Southern Medical University, 1023 South Shatai Road, Guangzhou 510515, Guangdong, China. [4]Department of Orthopedics, Clinical Research Centre, Zhujiang Hospital, Southern Medical University, 253 Gongye Road, Guangzhou 510282, Guangdong, China. [5]Department of Applied Physics, The Hong Kong Polytechnic University, Kowloon 999077, Hong Kong, China.
出处：
DOI： 10.1186/s12951-022-01396-8
ISSN：

关键词： Spinal cord injury Molybdenum sulfide/oxidized graphene Hydrogel Conductive and mechanical adaptation Spinal cord reparation Anti-inflammation

摘要：
A sort of composite hydrogel with good biocompatibility, suppleness, high conductivity, and anti-inflammatory activity based on polyvinyl alcohol (PVA) and molybdenum sulfide/graphene oxide (MoS2/GO) nanomaterial has been developed for spinal cord injury (SCI) restoration. The developed (MoS2/GO/PVA) hydrogel exhibits excellent mechanical properties, outstanding electronic conductivity, and inflammation attenuation activity. It can promote neural stem cells into neurons differentiation as well as inhibit the astrocytes development in vitro. In addition, the composite hydrogel shows a high anti-inflammatory effect. After implantation of the composite hydrogel in mice, it could activate the endogenous regeneration of the spinal cord and inhibit the activation of glial cells in the injured area, thus resulting in the recovery of locomotor function. Overall, our work provides a new sort of hydrogels for SCI reparation, which shows great promise for improving the dilemma in SCI therapy.© 2022. The Author(s).

基金：
National Natural Science Foundation of China [52002133, 81972080]; Guangdong Basic and Applied Basic Research Foundation [2019A1515110328]; Research Program of PLA [20QNPY083]; Science and Technology Planning Project of Guangdong Province [2017B030314139]; Natural Science Foundation of Guangdong Province [2015A030312004]; Science and Technology Planning Project of Guangzhou [202102080527, 202002030304]; Medical research foundation of Guangdong province [A2019228]; Intramural technology program of Southern Theater Command General Hospital [2021NZC030]
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 2 区 工程技术
小类 | 2 区 生物工程与应用微生物 3 区 纳米科技
最新[2025]版：
大类 | 1 区 生物学
小类 | 1 区 生物工程与应用微生物 2 区 纳米科技
JCR分区：
出版当年[2020]版：
Q1 NANOSCIENCE & NANOTECHNOLOGY Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
最新[2023]版：
Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q1 NANOSCIENCE & NANOTECHNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Guangdong Key Lab of Orthopedic Technology and Implant Materials, Key Laboratory of Trauma & Tissue Repair of Tropical Area of PLA, Orthopedic Center, General Hospital of Southern Theater Command of PLA, Guangzhou 510010, Guangdong, China.
共同第一作者：
通讯作者：
通讯机构： [1]Guangdong Key Lab of Orthopedic Technology and Implant Materials, Key Laboratory of Trauma & Tissue Repair of Tropical Area of PLA, Orthopedic Center, General Hospital of Southern Theater Command of PLA, Guangzhou 510010, Guangdong, China. [3]Southern Medical University, 1023 South Shatai Road, Guangzhou 510515, Guangdong, China.
推荐引用方式(GB/T 7714)：
Chen Lingling,Wang Wanshun,Lin Zefeng,et al.Conducting molybdenum sulfide/graphene oxide/polyvinyl alcohol nanocomposite hydrogel for repairing spinal cord injury.[J].JOURNAL OF NANOBIOTECHNOLOGY.2022,20(1):doi:10.1186/s12951-022-01396-8.
APA：
Chen Lingling,Wang Wanshun,Lin Zefeng,Lu Yao,Chen Hu...&Zhang Tao.(2022).Conducting molybdenum sulfide/graphene oxide/polyvinyl alcohol nanocomposite hydrogel for repairing spinal cord injury..JOURNAL OF NANOBIOTECHNOLOGY,20,(1)
MLA：
Chen Lingling,et al."Conducting molybdenum sulfide/graphene oxide/polyvinyl alcohol nanocomposite hydrogel for repairing spinal cord injury.".JOURNAL OF NANOBIOTECHNOLOGY 20..1(2022)

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