机构:[1]State Key Laboratory of Structural Chemistry, and Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, University of Chinese Academy of Sciences, Fuzhou 350100, China[2]Pingxiang University, Pingxiang 337055, China[3]Orthopedics Department, Guangdong Provincial Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China广东省中医院
Copper-catalyzed divergent annulations between alpha-diketones and alkynyl alpha-diketones have been achieved, delivering a series of highly functionalized and biologically important cis-hexahydro-2H-cyclopenta[b]furan (HCPF) and 2-hydroxydihydrofuran-3(2H)-one (HDFO) products with high levels of stereoselectivity under identical conditions. The protocol features the use of earth-abundant copper catalyst, mild conditions, shortening synthetic routes in constructing different molecular frameworks, and reducing the corresponding possible waste production. The substituents of the nucleophilic alpha-diketones play crucial roles in switching the reaction pathways. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
基金:
National Natural Science Foundation of China [22071242, 21871260]; Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000 0 0 0]; Fujian Natural Science Foundation [2018J05035]; Science and Technology Research Program of the Education Department of Jiangxi Province [GJJ1991151]
第一作者机构:[1]State Key Laboratory of Structural Chemistry, and Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, University of Chinese Academy of Sciences, Fuzhou 350100, China
通讯作者:
推荐引用方式(GB/T 7714):
Kong Xiangwen,Yu Fang,Niu Shengtong,et al.Copper-catalyzed diversified annulations between α-diketones and alkynyl α-diketones[J].CHINESE CHEMICAL LETTERS.2022,33(6):2997-3002.doi:10.1016/j.cclet.2021.11.070.
APA:
Kong, Xiangwen,Yu, Fang,Niu, Shengtong,Gong, Fan,Yang, Shuang...&Fang, Xinqiang.(2022).Copper-catalyzed diversified annulations between α-diketones and alkynyl α-diketones.CHINESE CHEMICAL LETTERS,33,(6)
MLA:
Kong, Xiangwen,et al."Copper-catalyzed diversified annulations between α-diketones and alkynyl α-diketones".CHINESE CHEMICAL LETTERS 33..6(2022):2997-3002