高级检索
当前位置: 首页 > 详情页

Exploration of the Shared Gene and Molecular Mechanisms Between Endometriosis and Recurrent Pregnancy Loss.

文献详情

资源类型:
WOS体系:
Pubmed体系:

收录情况: ◇ SCIE

机构: [1]Department of Rheumatology, The First Hospital of Jilin University, Changchun, China. [2]Department of Pediatrics, Shenzhen University General Hospital, Shenzhen, China. [3]Department of Obstetrics and Gynecology, Shenzhen University General Hospital, Shenzhen, China. [4]Guangzhou University of Chinese Medicine, Guangzhou, China. [5]School of Future Technology, University of Chinese Academy of Sciences, Beijing, China. [6]Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen, China. [7]Shenzhen Key Laboratory, Shenzhen University General Hospital, Shenzhen, China.
出处:
ISSN:

关键词: endometriosis recurrent pregnancy loss WGCNA PI3K-Akt signaling pathway platelet activation miRNAs-mRNAs

摘要:
Endometriosis (EMs) is a common benign gynecological disease in women of childbearing age, which usually causes pelvic pain, secondary dysmenorrhea, and infertility. EMs has been linked to recurrent pregnancy loss (RPL) in epidemiological data. The relationship of both, however, remains unknown. The purpose of this study is to explore the underlying pathological mechanisms between EMs and RPL. We searched Gene Expression Omnibus (GEO) database to obtain omics data of EMs and RPL. Co-expression modules for EMs and RPL were investigated by using weighted gene co-expression network analysis (WGCNA). The intersections of gene modules with the strong correlation to EMs or RPL obtained by WGCNA analysis were considered as shared genes. MicroRNAs (miRNAs) and their corresponding target genes linked to EMs and RPL were found though the Human MicroRNA Disease Database (HMDD) and the miRTarbase database. Finally, we constructed miRNAs-mRNAs regulatory networks associated with the two disorders by using the intersection of previously obtained target genes and shared genes. We discovered as significant modules for EMs and RPL, respectively, by WGCNA. The energy metabolism might be the common pathogenic mechanism of EMs and RPL, according to the findings of a Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. We discovered several target genes that might be linked to these two disorders, as well as the potential mechanisms. RAB8B, GNAQ, H2AFZ, SUGT1, and LEO1 could be therapeutic candidates for RPL and EMs. The PI3K-Akt signaling pathway and platelet activation were potentially involved in the mechanisms of EM-induced RPL. Our findings for the first time revealed the underlying pathological mechanisms of EM-induced RPL and identified several useful biomarkers and potential therapeutic targets.Copyright © 2022 Ye, Meng, Zhang, He, Zhao, Yu, Liang, Li and Wang.

基金:
语种:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2021]版:
大类 | 2 区 农林科学
小类 | 2 区 兽医学
最新[2025]版:
大类 | 2 区 农林科学
小类 | 2 区 兽医学
JCR分区:
出版当年[2020]版:
Q1 VETERINARY SCIENCES
最新[2023]版:
Q1 VETERINARY SCIENCES

影响因子: 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者:
第一作者机构: [1]Department of Rheumatology, The First Hospital of Jilin University, Changchun, China.
通讯作者:
通讯机构: [3]Department of Obstetrics and Gynecology, Shenzhen University General Hospital, Shenzhen, China. [6]Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen, China. [7]Shenzhen Key Laboratory, Shenzhen University General Hospital, Shenzhen, China.
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:2022 今日访问量:0 总访问量:648 更新日期:2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持:重庆聚合科技有限公司 地址:广州市越秀区大德路111号