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Customized Design 3D Printed PLGA/Calcium Sulfate Scaffold Enhances Mechanical and Biological Properties for Bone Regeneration

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资源类型：
Pubmed体系：
作者：
Liu Tao[1] * ; Li Zhan[2] * ; Zhao Li[3] * ; Chen Zehua[4] * ; Lin Zefeng[5] ; Li Binglin[3,5] ; Feng Zhibin[1] ; Jin Panshi[1] ; Zhang Jinwei[1] ; Wu Zugui[4] ; Wu Huai[6] ; Xu Xuemeng[6] ; Ye Xiangling[4] ; Zhang Ying[1,3] ;
机构： [1]General Hospital of Southern Theatre Command of PLA, The First School of Clinical Medicine, Southern Medical University, Guangzhou, China. [2]General Hospital of Southern Theatre Command of PLA, Guangzhou University of Chinese Medicine, Guangzhou, China. [3]Department of Trauma Orthopedics, Hospital of Orthopedics, General Hospital of Southern Theatre Command of PLA, Guangzhou, China. [4]The Fifth Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China. [5]Guangdong Key Lab of Orthopedic Technology and Implant Materials, General Hospital of Southern Theatre Command of PLA, Guangzhou, China. [6]Department of Orthopedics, Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou, China.
出处：
DOI： 10.3389/fbioe.2022.874931
ISSN：

关键词： bone defect 3D printing scaffold polylactic glycolic acid copolymer calcium sulfate mechanical properties biological properties

摘要：
Polylactic glycolic acid copolymer (PLGA) has been widely used in tissue engineering due to its good biocompatibility and degradation properties. However, the mismatched mechanical and unsatisfactory biological properties of PLGA limit further application in bone tissue engineering. Calcium sulfate (CaSO4) is one of the most promising bone repair materials due to its non-immunogenicity, well biocompatibility, and excellent bone conductivity. In this study, aiming at the shortcomings of activity-lack and low mechanical of PLGA in bone tissue engineering, customized-designed 3D porous PLGA/CaSO4 scaffolds were prepared by 3D printing. We first studied the physical properties of PLGA/CaSO4 scaffolds and the results showed that CaSO4 improved the mechanical properties of PLGA scaffolds. In vitro experiments showed that PLGA/CaSO4 scaffold exhibited good biocompatibility. Moreover, the addition of CaSO4 could significantly improve the migration and osteogenic differentiation of MC3T3-E1 cells in the PLGA/CaSO4 scaffolds, and the PLGA/CaSO4 scaffolds made with 20 wt.% CaSO4 exhibited the best osteogenesis properties. Therefore, calcium sulfate was added to PLGA could lead to customized 3D printed scaffolds for enhanced mechanical properties and biological properties. The customized 3D-printed PLGA/CaSO4 scaffold shows great potential for precisely repairing irregular load-bearing bone defects.Copyright © 2022 Liu, Li, Zhao, Chen, Lin, Li, Feng, Jin, Zhang, Wu, Wu, Xu, Ye and Zhang.

基金：
This work was supported by the Research Program of PLA (No. 20WQ030 and 2021NZC026); Natural Science Foundation of Guangdong Province of China (No. 2021A1515011545); Science and Technology Innovation Strategy Special Fund of Guangdong Province (No. 2021B1111610007); the National Natural Science Foundation of China (No. 81972080); the Research Foundation of Medical Science and Technology of Guangdong Province (No. 2020112693915296); the Science and Technology Planning Project of Guangdong Province (No. 2017B030314139).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 工程技术
小类 | 2 区 综合性期刊
最新[2025]版：
大类 | 3 区 生物学
小类 | 3 区 生物工程与应用微生物 4 区 工程：生物医学
第一作者：
第一作者机构： [1]General Hospital of Southern Theatre Command of PLA, The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.
共同第一作者：
通讯作者：
通讯机构： [1]General Hospital of Southern Theatre Command of PLA, The First School of Clinical Medicine, Southern Medical University, Guangzhou, China. [3]Department of Trauma Orthopedics, Hospital of Orthopedics, General Hospital of Southern Theatre Command of PLA, Guangzhou, China.
推荐引用方式(GB/T 7714)：
Liu Tao,Li Zhan,Zhao Li,et al.Customized Design 3D Printed PLGA/Calcium Sulfate Scaffold Enhances Mechanical and Biological Properties for Bone Regeneration[J].Frontiers in bioengineering and biotechnology.2022,10:874931.doi:10.3389/fbioe.2022.874931.
APA：
Liu Tao,Li Zhan,Zhao Li,Chen Zehua,Lin Zefeng...&Zhang Ying.(2022).Customized Design 3D Printed PLGA/Calcium Sulfate Scaffold Enhances Mechanical and Biological Properties for Bone Regeneration.Frontiers in bioengineering and biotechnology,10,
MLA：
Liu Tao,et al."Customized Design 3D Printed PLGA/Calcium Sulfate Scaffold Enhances Mechanical and Biological Properties for Bone Regeneration".Frontiers in bioengineering and biotechnology 10.(2022):874931

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