机构：[1]College of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.[2]Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou 510095, China.[3]State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510515, China.
α-Linolenic acid (ALA) is a natural essential fatty acid widely found in plant seed oils and beans, which shows positive anti-inflammatory and antiallergic effects. In our previous study, ALA was proven to bind tightly to the seven protein targets closely associated with allergic rhinitis (AR) by molecular docking, which indicates that ALA may have a potential role in the treatment of AR. A mouse model of AR induced by ovalbumin (OVA) was adopted in this study to explore the therapeutical effect and potential mechanism of ALA in treating AR. Results demonstrated that ALA remarkably relieved the nasal symptoms, reduced the OVA-sIgE level in the serum, relieved the histopathological injuries, and downregulated the mRNA expression levels of IL-6 and IL-1β in the nasal mucosa. ALA also remarkably moderated the imbalance of Th1/Th2 cells, increased the mRNA expression levels of T-bet and STAT1, and reduced GATA3 and STAT6. ALA was proven to have a substantial therapeutic effect on mice with AR, and the underlying mechanism was likely to be the regulation of Th1/Th2 imbalance through the JAK/T-bet/STAT1 and JAK/GATA3/STAT6 pathways. This study provides a specific experimental basis for the clinical use and drug development of ALA in the treatment of AR.
基金：
This research was funded by the National Natural Science Foundation of China (82004252),
the Guangdong Provincial Medical Science and Technology Research Fund (A2020456), and the Basic
and Applied Basic Research Foundation of Guangzhou Municipal Science and Technology Bureau
(2060206).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|3 区化学
小类|3 区生化与分子生物学3 区化学综合
最新[2025]版：
大类|3 区化学
小类|3 区生化与分子生物学3 区化学：综合
第一作者：
第一作者机构：[1]College of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Ren Mengyue,Wang Yi,Lin Lin,et al.α-Linolenic Acid Screened by Molecular Docking Attenuates Inflammation by Regulating Th1/Th2 Imbalance in Ovalbumin-Induced Mice of Allergic Rhinitis[J].Molecules (Basel, Switzerland).2022,27(18):doi:10.3390/molecules27185893.
APA：
Ren Mengyue,Wang Yi,Lin Lin,Li Shaoqiang&Ma Qinhai.(2022).α-Linolenic Acid Screened by Molecular Docking Attenuates Inflammation by Regulating Th1/Th2 Imbalance in Ovalbumin-Induced Mice of Allergic Rhinitis.Molecules (Basel, Switzerland),27,(18)
MLA：
Ren Mengyue,et al."α-Linolenic Acid Screened by Molecular Docking Attenuates Inflammation by Regulating Th1/Th2 Imbalance in Ovalbumin-Induced Mice of Allergic Rhinitis".Molecules (Basel, Switzerland) 27..18(2022)
