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PCDH9 suppresses melanoma proliferation and cell migration

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机构： [1]Dermatology Department, Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China. [2]College of Food and Health, Zhejiang Agriculture and Forestry University, Hangzhou, Zhejiang, China. [3]The Seventh Affiliated Hospital of Southern Medical University, Foshan, Guangdong, China. [4]Department of Surgery, University of Miami, Miami, FL, United States. [5]College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China. [6]Nano-drug Technology Research Center at Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.

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关键词： PCDH9 RAC1 melanoma cell suppression MMP2 MMP9 CCND1 (Cyclin D1)

摘要：

Melanoma has dramatically increased during last 30 years with low 5-year survival and prognosis rate.Melanoma cells (A375 and G361) were chosen as the in vitro model. The immunohistochemical (IHC) analysis and bioinformatics mining exhibited the suppression of PCDH9 on melanoma. The interference and overexpression of PCDH9 were infected by lentivirus. The effects of PCDH9 on melanoma cells were assessed in terms of alteration of PCDH9 such as cell viability, apoptosis, cell cycle, and wound-healing assay. Moreover, expressions of PCDH9 with other genes (MMP2, MMP9, CCND1, and RAC1) were also assessed by PCR.The alteration of PCDH9 has a negative correlation with MMP2, MMP9, and RAC1 but had a positive correlation with CCND1 (Cyclin D1) and apoptosis. Increase of PCDH9 could suppress melanoma cells and inhibit migration but not exert significant effects on cell cycle. IHC showed lower PCDH9 expression in melanoma tissue with main expression in cytoplasm.Overexpressed PCDH9 suppressed melanoma cells, and PCDH9 can be considered as an independent prognostic factor for melanoma; even re-expression of PCDH9 can serve as a potential therapeutic strategy for melanoma treatment.Copyright © 2022 Zhang, Yang, Liu, Islam, Zhu, Wang and Chen.

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出版当年[2021]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

最新[2025]版：

大类 | 3 区医学

小类 | 4 区肿瘤学

第一作者：

第一作者机构： [1]Dermatology Department, Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China. [2]College of Food and Health, Zhejiang Agriculture and Forestry University, Hangzhou, Zhejiang, China.

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通讯作者：

通讯机构： [5]College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China. [6]Nano-drug Technology Research Center at Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.

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PCDH9 suppresses melanoma proliferation and cell migration

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