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Decreased serum 4-Hydroxynonenal level as a biomarker for the progression of steroid-induced osteonecrosis of the femoral head

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资源类型：
Pubmed体系：
作者：
Xiao Fangjun[1,2] * ; Wei Tengfei[1,2] * ; Xiao Huan[3] ; He Wei[4,5] ; Wei Qiushi[6,7] ;
机构： [1]Guangzhou University of Chinese Medicine, Guangzhou, China. [2]Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, China. [3]Department of Orthopedics, Bijie Hospital of Chinese Medicine, Bijie, Guizhou, China. [4]Guangdong Research Institute for Orthopedics and Traumatology of Chinese Medicine, Guangzhou, China. [5]Department of Orthopaedics, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. [6]Guangdong Research Institute for Orthopedics and Traumatology of Chinese Medicine, Guangzhou, China. [7]Department of Orthopaedics, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
出处：
DOI： 10.1186/s13018-023-04153-1

关键词： Oxidative stress 4-Hydroxynonenal Steroid-induced osteonecrosis of the femoral head Biomarker Collapse

摘要：
Osteonecrosis of the femoral head (ONFH) is becoming a prevalent global health problem. 4-Hydroxynonenal (4-HNE) serves as a common marker of oxidative stress. This study aims to study the potential role of 4-HNE in the progression of steroid-induced osteonecrosis of the femoral head (SIONFH).Between April 2021 and December 2021, 64 subjects were enrolled in this cross-sectional case‒control study. Thirty-six patients were grouped based on the Association Research Circulation Osseous (ARCO) classification, and 28 healthy volunteers without hip pain or any lesions shown in anteroposterior and frog-leg lateral pelvic radiographs served as the normal control group. Bone hematoxylin-eosin (HE) staining, microcomputed tomography (micro-CT), immunohistochemistry, and levels of plasma 4-HNE were evaluated.The 4-HNE level was higher in the SIONFH group than in the normal control group (P < 0.001), and 4-HNE levels were significantly higher in SIONFH patients in the early stage of disease (stage II). The 4-HNE level was negatively correlated with ARCO stage (r = - 0.6875, P < 0.001). Immunohistochemistry revealed the presence of 4-HNE in the trabecular bone, osteocytes, and bone marrow.The 4-HNE level is negatively associated with ARCO stages. Lower levels of 4-HNE may serve as a critical biomarker for the progression of SIONFH.© 2023. BioMed Central Ltd., part of Springer Nature.

基金：
This work was granted from the project of the National Natural Science Foundation of China (Grant Nos. 81873327, 82004392, and 82274544), the Double First-class Discipline Construction Project of Guangzhou University of Chinese Medicine (Grant No. Z2015002), the major project of "Double First-class" and High-level University Discipline Collaborative Innovation Team of Guangzhou University of Chinese Medicine (Grant No. 2021XK05), the cultivated project of "Double First-class" and High-level University Discipline Collaborative Innovation Team of Guangzhou University of Chinese Medicine (Grant No. 2021XK41 and 2021XK46) and Bijie Science and Technology Bureau ‘the open competition project’ (no. BST Major Project No.1,2022) and Open Funding of Guangdong Research Institute for Orthopedics and Traumatology of Chinese Medicine (Grant Nos. GYH202101-01, GYH202101-04).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 3 区 骨科
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 骨科
第一作者：
第一作者机构： [1]Guangzhou University of Chinese Medicine, Guangzhou, China. [2]Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, China.
共同第一作者：
通讯作者：
通讯机构： [4]Guangdong Research Institute for Orthopedics and Traumatology of Chinese Medicine, Guangzhou, China. [5]Department of Orthopaedics, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. [6]Guangdong Research Institute for Orthopedics and Traumatology of Chinese Medicine, Guangzhou, China. [7]Department of Orthopaedics, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
推荐引用方式(GB/T 7714)：
Xiao Fangjun,Wei Tengfei,Xiao Huan,et al.Decreased serum 4-Hydroxynonenal level as a biomarker for the progression of steroid-induced osteonecrosis of the femoral head[J].Journal of orthopaedic surgery and research.2023,18(1):732.doi:10.1186/s13018-023-04153-1.
APA：
Xiao Fangjun,Wei Tengfei,Xiao Huan,He Wei&Wei Qiushi.(2023).Decreased serum 4-Hydroxynonenal level as a biomarker for the progression of steroid-induced osteonecrosis of the femoral head.Journal of orthopaedic surgery and research,18,(1)
MLA：
Xiao Fangjun,et al."Decreased serum 4-Hydroxynonenal level as a biomarker for the progression of steroid-induced osteonecrosis of the femoral head".Journal of orthopaedic surgery and research 18..1(2023):732

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