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Plasma 8-OHdG act as a biomarker for steroid-induced osteonecrosis of the femoral head

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资源类型：
Pubmed体系：
作者：
Peng Peng[1] * ; He Mincong[2,3] * ; Fang Weihua[1] ; Lai Mengqi[1] ; Xiao Fangjun[1] ; He Wei[2,3] ; Xiao Huan[4] ; Wei Qiushi[2,3] ;
机构： [1]Guangzhou University of Chinese Medicine, Guangzhou 510405, China [2]Guangdong Research Institute for Orthopedics and Traumatology of Chinese Medicine, Guangzhou 510378, China [3]Department of Orthopaedics, The Third Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510378, China [4]Department of Orthopedics, Bijie Traditional Chinese Medicine Hospital, Bijie 551700, China
出处：
DOI： 10.1186/s12891-023-06804-0

关键词： Steroid-induced osteonecrosis of the femoral head 8-hydroxy-2’-deoxyguanosine (8-OHdG) Oxidative stress Collapse

摘要：
Oxidative stress was closely related to the occurrence and development of Steroid-induced osteonecrosis of the femoral head (SIONFH). 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a important index of oxidative stress. The aim of this study is to investigate the role of 8-OHdG in the development of SIONFH.From May 2021 and November 2021, 33 patients diagnosed with SIONFH and 26 healthy controls were recruited in this study. Assessment included the radiography and pathology evaluation of clinical bone tissue, expression position and level of 8-OHdG, level of plasma 8-OHdG, as well as the receiver operating characteristic (ROC) curve.We observed that expression levels of 8-OHdG in bone samples decreased with Association Research Circulation Osseous (ARCO) stages. Plasma 8-OHdG levels were significantly increased in the SIONFH group compared to the healthy control group. Plasma 8-OHdG level of pre-collapse patients was higher than that of post-collapse patients, the decreased plasma 8-OHdG level was related to higher ARCO stages.Plasma 8-OHdG may represent potential biomarkers during SIONFH at different stages. Higher plasma 8-OHdG levels indicated early stage of SIONFH. The current study provided new clues for early diagnosis and treatment for SIONFH.© 2023. BioMed Central Ltd., part of Springer Nature.

基金：
This study was supported by the National Natural Science Foundation of China (grant number 81873327, 82004392, 82274544 and 81573996), the major project of “Double First-class” and High-level University Discipline Collaborative Innovation Team of Guangzhou University of Chinese Medicine (grant number 2021XK05), the cultivated project of “Double First-class” and High-level University Discipline Collaborative Innovation Team of Guangzhou University of Chinese Medicine (grant number 2021XK41 and 2021XK46), the Foundation of Guangdong Educational Committee for Youth Scientists (grant number 2019KQNCX017), and Bijie Science and Technology Bureau ’the open competition project’ (no. BST Major Project No.1,2022).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 4 区 骨科 4 区 风湿病学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 骨科 3 区 风湿病学
第一作者：
第一作者机构： [1]Guangzhou University of Chinese Medicine, Guangzhou 510405, China
共同第一作者：
通讯作者：
通讯机构： [2]Guangdong Research Institute for Orthopedics and Traumatology of Chinese Medicine, Guangzhou 510378, China [3]Department of Orthopaedics, The Third Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510378, China
推荐引用方式(GB/T 7714)：
Peng Peng,He Mincong,Fang Weihua,et al.Plasma 8-OHdG act as a biomarker for steroid-induced osteonecrosis of the femoral head[J].BMC musculoskeletal disorders.2023,24(1):808.doi:10.1186/s12891-023-06804-0.
APA：
Peng Peng,He Mincong,Fang Weihua,Lai Mengqi,Xiao Fangjun...&Wei Qiushi.(2023).Plasma 8-OHdG act as a biomarker for steroid-induced osteonecrosis of the femoral head.BMC musculoskeletal disorders,24,(1)
MLA：
Peng Peng,et al."Plasma 8-OHdG act as a biomarker for steroid-induced osteonecrosis of the femoral head".BMC musculoskeletal disorders 24..1(2023):808

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