详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

The causal relationship between sarcopenic obesity factors and benign prostate hyperplasia

12| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Beijing University of Chinese Medicine, Beijing, China. [2]The Second School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing, China. [3]Graduate School, Beijing University of Chinese Medicine, Beijing, China. [4]Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. [5]Department of Spinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China. [6]Department of Acupuncture and Moxibustion, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China. [7]Singa Care Medical, Singapore, Singapore. [8]Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury, Department of Orthopaedic Surgery, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China. [9]Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, Orthopaedic Research Institute/Department of Spinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

出处：

DOI：

ISSN：

关键词： sarcopenic obesity basal metabolic rate appendicular lean mass benign prostatic hyperplasia genome-wide association study mendelian randomization

摘要：

Both benign prostatic hyperplasia (BPH) and sarcopenic obesity (SO) are common conditions among older adult/adults males. The prevalent lifestyle associated with SO is a significant risk factor for the development of BPH. Therefore, we investigated the causal relationship between SO factors and BPH.The instrumental variables for SO factors were selected using the inverse variance-weighted method, which served as the primary approach for Mendelian randomization analysis to assess the causal effect based on summary data derived from genome-wide association studies of BPH.The increase in BMR (OR = 1.248; 95% CI = (1.087, 1.432); P = 0.002) and ALM (OR = 1.126; 95% CI = (1.032, 1.228); P = 0.008) was found to be associated with an elevated risk of BPH. However, no genetic causality between fat-free mass distribution, muscle mass distribution, and BPH was observed.Our findings indicate that a genetic causal association between BMR, ALM and BPH. BMR and ALM are risk factors for BPH. The decrease in BMR and ALM signified the onset and progression of SO, thus SO is a protective factor for BPH.Copyright © 2023 Rao, Xu, Zhang, Zhou, Huang, Toh, Zheng and Zhou.

基金：

语种：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2022]版：

大类 | 2 区医学

小类 | 2 区内分泌学与代谢

最新[2025]版：

大类 | 3 区医学

小类 | 3 区内分泌学与代谢

JCR分区：

出版当年[2021]版：

Q1 ENDOCRINOLOGY & METABOLISM

最新[2023]版：

Q2 ENDOCRINOLOGY & METABOLISM

影响因子： 3.9 最新[2023版] 4.9 最新五年平均 6.055 出版当年[2021版] 6.335 出版当年五年平均 5.555 出版前一年[2020版] 5.2 出版后一年[2022版]

第一作者：

第一作者机构： [1]Beijing University of Chinese Medicine, Beijing, China. [2]The Second School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing, China.

共同第一作者：

通讯作者：

通讯机构： [8]Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury, Department of Orthopaedic Surgery, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China. [9]Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, Orthopaedic Research Institute/Department of Spinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

The causal relationship between sarcopenic obesity factors and benign prostate hyperplasia

文献详情

相关文献