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Qualitative and Quantitative Measures in the Infrapatellar Fat Pad in Older Adults: Associations with Knee Pain, Radiographic Osteoarthritis, Kinematics, and Kinetics of the Knee

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资源类型：
Pubmed体系：
作者：
Wang Zhengming[1,2] * ; Lu Jiehang[1,2] ; Li Zhengyan[1,2] ; Wang Yuanyuan[3] ; Ge Haiya[1,2] ; Zhang Min[1,2] ; Wang Rui[4,5] ; Gu Yong[6] ; Ding Lipeng[1,2] ; Ren Woxing[1,2] ; Shen Zhibi[1,2] ; Du Guoqing[1] ; Wu Yufeng[7] ; Zhan Hongsheng[1,2] ;
机构： [1]Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Traumatology & Orthopedics, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. [2]Shanghai University of Traditional Chinese Medicine, Shanghai, China. [3]Guanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Department of Orthopedic Surgery, Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China. [4]Translational Medical Innovation Center, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Jiangsu, China. [5]Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. [6]Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan, Guangdong, China. [7]Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Traumatology & Orthopedics, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. Electronic address: zhanhongsheng@shutcm.edu.cn.
出处：
DOI： 10.1016/j.acra.2024.02.013
ISSN：

关键词： Infrapatellar fat pad Osteoarthritis Symptom Structure Kinematics Kinetics

摘要：
The purpose of this study is to delineate cross-sectional associations between qualitative and quantitative measures of the infrapatellar fat pad (IPFP) and knee symptoms, structure, kinematics, and kinetics in older adults.Ninety eligible subjects (90 knees, mean age 54.0 years, 68.9% female) were examined at our center. We used T2-weighted fat-suppressed magnetic resonance imaging (MRI) to evaluate signal intensity alteration, maximum sagittal area, and depth of the IPFP. Symptomatic osteoarthritis (SOA) was a pain subscale score greater than 0 on the Western Ontario McMaster Osteoarthritis Index. A Kellgren-Lawrence grade ≥ 2 identified incident radiographic osteoarthritis (iROA). Three-dimensional gait data were employed to analyze knee joint kinematics and kinetics. Correlation and regression analyzes assessed associations between IPFP measurements and SOA, iROA, kinematics, and kinetics.There were strong and positive associations between IPFP signal intensity alteration and both SOA and iROA in multivariable regression analyzes [OR (95% CI): 2.849 (1.440 to 5.636), 2.356 (1.236 to 4.492), respectively]. Conversely, a significant negative correlation was observed between IPFP maximum area and flexion angle [B (95%CI): - 1.557 (-2.549 to -0.564)]. Moreover, adjusting for covariates did not reveal any significant correlation between IPFP parameters and other indicators (P > 0.05, respectively).IPFP signal intensity alteration and area were associated with knee clinical symptoms, structural abnormalities, and flexion angle in adults over 40, respectively. These findings suggest that IPFP may be a crucial imaging biomarker in early and middle knee osteoarthritis.Copyright © 2024 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.

基金：
Shanghai Municipal Health Commission [20MC1920600, shslczdzk03901, and ZY (2021–2023)− 0209–02], the National Natural Science Foundation (82074466 and 82174403), and Shanghai University of Traditional Chinese Medicine (GJ2023017).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 2 区 核医学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 核医学
第一作者：
第一作者机构： [1]Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Traumatology & Orthopedics, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. [2]Shanghai University of Traditional Chinese Medicine, Shanghai, China.
通讯作者：
通讯机构： [1]Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Traumatology & Orthopedics, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. [2]Shanghai University of Traditional Chinese Medicine, Shanghai, China.
推荐引用方式(GB/T 7714)：
Wang Zhengming,Lu Jiehang,Li Zhengyan,et al.Qualitative and Quantitative Measures in the Infrapatellar Fat Pad in Older Adults: Associations with Knee Pain, Radiographic Osteoarthritis, Kinematics, and Kinetics of the Knee[J].Academic Radiology.2024,doi:10.1016/j.acra.2024.02.013.
APA：
Wang Zhengming,Lu Jiehang,Li Zhengyan,Wang Yuanyuan,Ge Haiya...&Zhan Hongsheng.(2024).Qualitative and Quantitative Measures in the Infrapatellar Fat Pad in Older Adults: Associations with Knee Pain, Radiographic Osteoarthritis, Kinematics, and Kinetics of the Knee.Academic Radiology,,
MLA：
Wang Zhengming,et al."Qualitative and Quantitative Measures in the Infrapatellar Fat Pad in Older Adults: Associations with Knee Pain, Radiographic Osteoarthritis, Kinematics, and Kinetics of the Knee".Academic Radiology .(2024)

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