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SAG expression associates with COPB2-related signaling and a poorer prognosis in breast cancer

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收录情况： ◇ SCIE

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机构： [1]Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang, China [2]Institute of Translational Medicine, Zhejiang University, School of Medicine, Hangzhou 310029, Zhejiang, China [3]Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang, China [4]Departmant of Galactophore Surgery, The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangdong 510120, China [5]Departmant of Plastic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang, China

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关键词： breast cancer COPB2 prognosis proliferation SAG

摘要：

SAG is an essential RING component of the Cullin-RING ligase (CRL) E3 ubiquitin ligase complex, which regulates diverse signaling pathways and biological processes, including cell apoptosis, embryonic development, angiogenesis, and tumorigenesis. In the present study, we revealed that SAG gene expression is upregulated in breast cancer cells and that SAG overexpression is associated with significant poorer survival in breast cancer, especially the luminal A subtype. We also detected highly correlated co-overexpression of SAG and COPB2 in breast cancers. Subsequent in vitro experiments demonstrated that SAG and COPB2 act cooperatively to stimulate breast cancer cell proliferation, migration and invasion. Our findings suggest that levels of SAG and COPB2 expression may be useful prognostic indicators in breast cancers and that SAG may be involved in COPB2-related signaling during breast cancer development.

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出版当年[2019]版：

大类 | 2 区医学

小类 | 2 区老年医学 3 区细胞生物学

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无

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出版当年[2018]版：

Q1 GERIATRICS & GERONTOLOGY Q1 CELL BIOLOGY

最新[2023]版：

Q2 CELL BIOLOGY Q2 GERIATRICS & GERONTOLOGY

影响因子： 3.9 最新[2023版] 4.9 最新五年平均 5.515 出版当年[2018版] 5.543 出版当年五年平均 5.179 出版前一年[2017版] 4.831 出版后一年[2019版]

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第一作者机构： [1]Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang, China

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