机构：[1]Stroke Biological Recovery Laboratory, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, MA, USA[2]Seventh People’s Hospital of Shanghai University of TCM, Shanghai, PR China[3]Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai, PR China[4]Fudan University, Shanghai, PR China[5]Southern Medical University, Shenzhen, PR China南方医科大学深圳医院深圳医学信息中心[6]Southwest Hospital, Third Military Medical University, Chongqing, PR China[7]MGH Institute of Health Professions, Boston, MA, USA[8]Shenzhen People’s Hospital, Clinical Medical College of Jinan University, Shenzhen, Guangdong Province, PR China深圳市人民医院深圳医学信息中心[9]Kerry Rehabilitation Medicine Research Institute, Shenzhen, Guangdong, PR China[10]Dapeng New District Nan’ao People’s Hospital, Shenzhen, Guangdong, PR China[11]University of Shanghai for Science and Technology, Shanghai, PR China[12]Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA
Background and purpose. The identification of a genetic role for cognitive outcome could influence the design of individualized treatment in poststroke rehabilitation. The aim of this study is to determine whether brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is independently associated with poststroke functional outcome. Methods. A total of 775 stroke patients with genomic data were identified from the Partners HealthCare Biobank, which contains a large number of genotypes from Biobank's consented patients. Of 775 stroke patients who met the inclusion/exclusion criteria, 86 were enrolled. Functional outcomes were assessed using the Functional Independence Measure scores at the time of admission and discharge. Logistic and linear regression models adjusted for covariate variables, including age, sex, and medical conditions, were used to evaluate the association between BDNF Val66Met and functional outcome. Results. We detected a significant correlation between Met alleles and lower cognitive function at discharge in both ischemic and hemorrhagic stroke patients. Genotyping findings confirmed that BDNF Met allele frequency was higher in contrast to Val/Val allele frequency in lower cognitive functional recovery. Furthermore, after adjusting for covariate variables, BDNF Met alleles were found to be associated with lower cognitive outcome [P = .003; odds ratio (OR) = 5.95 (1.81-19.52)] and recovery [P = .006; OR = 3.16 (1.4-7.15)], especially with lower problem solving, expression, and social recovery in all stroke patients. Conclusions. Met allele carriers exhibited impaired poststroke cognitive function. The BDNF genotype may be a useful predictor of cognitive function in inpatient poststroke rehabilitation.
基金：
The authors disclosed receipt of the following financial support
for the research, authorship, and/or publication of this article: This
study was undertaken and completed at Spaulding Rehabilitation
Hospital, the teaching affiliate of Harvard Medical School, MA.
Funding to conduct the study was partially supported by the
Harvard Catalyst/The Harvard Clinical and Translational Science
Center, National Center for Research Resources and the National
Center for Advancing Translational Sciences, National Institutes of Health (Award UL1 TR001102); Harvard University and its
affiliated academic health care centers; and Fundamental Research
Funds for the Central Universities (Grant12ykpy39). The content
is solely the responsibility of the authors and does not necessarily
represent the official views of Harvard Catalyst, Harvard
University, and its affiliated academic health care centers or the
National Institutes of Health. Zhenxiang Han was supported by the
Outstanding Leaders Training Program of Pudong Health Bureau
of Shanghai (Grant PWR12016-02).
第一作者机构：[1]Stroke Biological Recovery Laboratory, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, MA, USA[2]Seventh People’s Hospital of Shanghai University of TCM, Shanghai, PR China
共同第一作者：
通讯作者：
通讯机构：[1]Stroke Biological Recovery Laboratory, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, MA, USA[12]Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA[*1]Stroke Biological Recovery Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Teaching Affiliate of Harvard Medical School, 300 First Avenue, Charlestown, MA 200137, USA.
推荐引用方式(GB/T 7714)：
Zhenxiang Han,Lili Qi,Qinfeng Xu,et al.BDNF Met allele Is Associated With Lower Cognitive Function in Poststroke Rehabilitation[J].NEUROREHABILITATION AND NEURAL REPAIR.2020,34(3):247-259.doi:10.1177/1545968320902127.
APA：
Zhenxiang Han,Lili Qi,Qinfeng Xu,Mingzhu Xu,Lei Cai...&Qing Mei Wang.(2020).BDNF Met allele Is Associated With Lower Cognitive Function in Poststroke Rehabilitation.NEUROREHABILITATION AND NEURAL REPAIR,34,(3)
MLA：
Zhenxiang Han,et al."BDNF Met allele Is Associated With Lower Cognitive Function in Poststroke Rehabilitation".NEUROREHABILITATION AND NEURAL REPAIR 34..3(2020):247-259
医学