机构：[1]School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China[2]Department of Clinical Laboratory, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510006, China大德路总院检验科大德路总院检验科广东省中医院[3]MOE Joint International Research Laboratory of Synthesis Biology and Medicine, South China University of Technology, Guangzhou, 510006, PR China
Two silver(I)-voriconazole (Vor) coordination complexes, namely [Ag(Vor)(2)](n)(ClO4)(n) (1) and [Ag-2(Vor)(4)](n)(NO3)(2n) (2), were synthesized and structurally characterized by X-ray single-crystal and powder diffraction, H-1 nuclear magnetic resonance, and infrared spectra. Both complexes featured an equimolar stoichiometry between Ag(I) ion and Vor within 2-D layer-like arrays, in which voriconazole exhibited unique and different coordination modes (mono-/tri-dentate modes in 1 and mono-/bi-/tri-dentate modes in 2). The perchlorate and nitrate anions were embedded in the two-dimensional plane. The results of antifungal studies demonstrated that both complexes possessed higher activity against voriconazole-resistant fungi than voriconazole alone, which might be caused by inhibiting the efflux pump activity of resistant fungi. Additionally, both silver(I) complexes showed no significant cytotoxicity on HaCaT cells in the MIC90 range for 24 h. These studies suggested that silver(I)-voriconazole coordination complexes were promising candidates as antifungal agents to resistant fungi. (C) 2020 Elsevier B.V. All rights reserved.
基金：
Foundation of Guangdong Science and Technology Department of China [2016A010121004, 2019B020201002]; Undergraduate Innovative and Entrepreneurial Training Program
第一作者机构：[1]School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China
通讯作者：
通讯机构：[1]School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China[3]MOE Joint International Research Laboratory of Synthesis Biology and Medicine, South China University of Technology, Guangzhou, 510006, PR China[*1]School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China.
推荐引用方式(GB/T 7714)：
Ou Yang-Hui,Du Rong-Kai,Zhang Shi-Pei,et al.Synthesis, crystal structure and in vitro antifungal activity of two-dimensional silver(I)-voriconazole coordination complexes[J].JOURNAL OF MOLECULAR STRUCTURE.2020,1215:doi:10.1016/j.molstruc.2020.128229.
APA：
Ou, Yang-Hui,Du, Rong-Kai,Zhang, Shi-Pei,Ling, Yun,Li, Shan...&Zhang, Lei.(2020).Synthesis, crystal structure and in vitro antifungal activity of two-dimensional silver(I)-voriconazole coordination complexes.JOURNAL OF MOLECULAR STRUCTURE,1215,
MLA：
Ou, Yang-Hui,et al."Synthesis, crystal structure and in vitro antifungal activity of two-dimensional silver(I)-voriconazole coordination complexes".JOURNAL OF MOLECULAR STRUCTURE 1215.(2020)
