机构：[1]School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.[2]Key Laboratory of State Administration of Traditional Chinese Medicine for Production & Development of Cantonese Medicinal Materials, Guangzhou, Guangdong, China.[3]School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.[4]National Clinical Research Center for Kidney Disease, Nanfang Hospital, Guangzhou, Guangdong, China.[5]Guangdong Provincial Clinical Research Center for Kidney Disease, Guangzhou, Guangdong, China.[6]Guangdong Eco-Engineering Polytechnic, Guangzhou, Guangdong, China.[7]Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, China.[8]Lei Yun Shang Pharmaceutical Group Co., Ltd, Suzhou, Jiangsu, China.[9]School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.[10]CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, Chinese Academy of Sceinces, South China Sea Institute of Oceanology, Guangdong, Guangzhou, China.
Hypoxylon vinosopulvinatum DYR-1-7 is a endophytic fungus isolated from the Cinnamomum cassia Presl and has an inhibitory effect on Lasiodiplodia pseudotheobromae. Three new furanones, hypoxylonone A-C (1-3), as well as three known compounds (4-6), were isolated from an EtOAc extract of H. vinosopulvinatum DYR-1-7. The structures were determined by spectroscopic data analysis using UV, IR, 1D-, 2D-NMR and HR-ESI-MS. The absolute configurations of 1-3 were elucidated by electronic circular dichroism (ECD) analyses. In the antifungal bioassay, Hypoxylonone B and C exhibited strong inhibitory effects on L. pseudotheobromae with IC50 value at the concentration of 1.01 and 2.40 μg/mL, respectively. Compound 6 showed medium antifungal activity with IC50 value at the concentration of 10.67 μg/mL on Fusarium oxysporum. Compounds 3 and 4 displayed medium antifungul effects on Candida albicans.
基金：
This work was supported by the ability establishment of sustainable use for valuable Chinese medicine resources (No.2060302); Natural Science Foundation of Guangdong Province (No.2022A1515011397); Guangzhou Basic and Applied Basic Research Foundation (No.202201010519); Open Project of Guangdong Key Laboratory of Marine Materia Medica (No.LMM2021-6); Guangdong Provincial University Young Innovative Talents Project (No.2021KQNCX036); College Students’ innovation and entrepreneurship training program (No.S202010573036).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|3 区化学
小类|3 区应用化学4 区药物化学
最新[2025]版：
大类|3 区化学
小类|3 区应用化学4 区药物化学
第一作者：
第一作者机构：[1]School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.[2]Key Laboratory of State Administration of Traditional Chinese Medicine for Production & Development of Cantonese Medicinal Materials, Guangzhou, Guangdong, China.[3]School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
共同第一作者：
通讯作者：
通讯机构：[1]School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.[2]Key Laboratory of State Administration of Traditional Chinese Medicine for Production & Development of Cantonese Medicinal Materials, Guangzhou, Guangdong, China.
推荐引用方式(GB/T 7714)：
Lv Jia,Zhou Hong,Dong Limei,et al.Three new furanones from endophytic fungus Hypoxylon vinosopulvinatum DYR-1-7 from Cinnamomum cassia with their antifungal activity[J].Natural product research.2023,1-8.doi:10.1080/14786419.2023.2218530.
APA：
Lv Jia,Zhou Hong,Dong Limei,Wang Hao,Yang Li...&Luo Bi.(2023).Three new furanones from endophytic fungus Hypoxylon vinosopulvinatum DYR-1-7 from Cinnamomum cassia with their antifungal activity.Natural product research,,
MLA：
Lv Jia,et al."Three new furanones from endophytic fungus Hypoxylon vinosopulvinatum DYR-1-7 from Cinnamomum cassia with their antifungal activity".Natural product research .(2023):1-8
