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Oroxylin A Inhibits Allergic Airway Inflammation in Ovalbumin (OVA)-Induced Asthma Murine Model

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收录情况： ◇ SCIE

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机构： [1]Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng 252000, Shandong, China [2]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Academy of Chinese Medical Sciences), Guangzhou 510006, Guangdong, China [3]Liaocheng City Food and Drug Inspection and Testing Center, Liaocheng 252000, Shandong, China

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关键词： oroxylin A OVA asthma NF-kappa B

摘要：

Oroxylin A, a natural flavonoid isolated from the medicinal herb Scutellaria baicalensis Georgi, has been reported to have anti-inflammatory property. In this study, we aimed to investigate the protective effects and mechanism of oroxylin A on allergic inflammation in OVA-induced asthma murine model. BABL/c mice were sensitized and airway-challenged with OVA to induce asthma. Oroxylin A (15, 30, and 60 mg/kg) was administered by oral gavage 1 h before the OVA treatment on day 21 to 23. The results showed that oroxylin A attenuated OVA-induced lung histopathologic changes, airway hyperresponsiveness, and the number of inflammatory cells. Oroxylin A also inhibited the levels of IL-4, IL-5, IL-13, and OVA-specific IgE in BALF. Furthermore, oroxylin A significantly inhibited OVA-induced NF-kappa B activation. In conclusion, these results suggested that oroxylin A inhibited airway inflammation in OVA-induced asthma murine model by inhibiting NF-kappa B activation. These results suggested that oroxylin A was a potential therapeutic drug for treating allergic asthma.

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出版当年[2015]版：

大类 | 3 区医学

小类 | 4 区细胞生物学 4 区免疫学

最新[2025]版：

大类 | 2 区医学

小类 | 3 区细胞生物学 3 区免疫学

JCR分区：

出版当年[2014]版：

Q3 CELL BIOLOGY Q3 IMMUNOLOGY

最新[2023]版：

Q2 CELL BIOLOGY Q2 IMMUNOLOGY

影响因子： 4.5 最新[2023版] 4.6 最新五年平均 2.208 出版当年[2014版] 2.109 出版当年五年平均 1.921 出版前一年[2013版] 2.618 出版后一年[2015版]

第一作者：

第一作者机构： [1]Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng 252000, Shandong, China

通讯作者：

通讯机构： [2]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Academy of Chinese Medical Sciences), Guangzhou 510006, Guangdong, China [*1]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Academy of Chinese Medical Sciences), Guangzhou 510006, Guangdong, China

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