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Dendrobium officinale polysaccharides attenuate learning and memory disabilities via anti-oxidant and anti-inflammatory actions

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ SSCI

作者：
Liang, Jian[1] * ; Wu, Yanfang[1] * ; Yuan, Han[1] * ; Yang, Yiqi[3] ; Xiong, Qingping[1] ; Liang, Chuyan[4] ; Li, Zhimeng[6] ; Li, Cantao[2] ; Zhang, Guifang[1] ; Lai, Xiaoping[1] ; Hu, Youdong[5] ; Hou, Shaozhen[1,2,*1] ;
机构： [1]Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, and Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China [2]School of pharmaceutical sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China [3]The second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China [4]The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510080, Guangdong, China [5]Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an 223002, Jiangsu, PR China [6]The Fifth People's Hospital of Tangshan, Tangshan 063004, Hebei, PR China
出处：
DOI： 10.1016/j.ijbiomac.2018.12.230
ISSN：

关键词： Dendrobium officinale Polysaccharides Learning and memory impairment Oxidative stress Neuro-inflammation

摘要：
The aim of this study was to explore the therapeutic effect and underling mechanism of Dendrobium officinale polysaccharides (DOPS) on two well-established animal models of learning and memory disabilities. Model of estrogen deficiency caused learning and memory disability can be induced by ovariectomy in mice, and mice were injected subcutaneously with D-galactose, which can also cause cognitive decline. H&E staining and Nissl staining were employed to confirm the protective effect of DOPS on hippocampal neuron. Morris water maze test, biochemical analysis, immunohistochemistry and immunofluorescence assay were used to study the effect and underlying mechanism of DOPS on two different learning and memory impairment models. Administration of DOPS significantly improved learning and memory disability in both models. Further studies showed that DOPS could attenuate oxidative stress and reduce neuro-inflammation via up-regulating expressions of Nrf2/HO-1 pathway and inhibiting activation of astrocytes and microglia in ovariectomy- and D-galactose-induced cognitive decline. These findings suggest that DOPS have an appreciable therapeutic effect on learning and memory disabilities and its mechanism may be related to activate Nrf2/HO-1 pathway to reduce oxidative stress and neuro-inflammation. (C) 2018 Elsevier B.V. All rights reserved.

基金：
Guangdong Province Universities and Colleges the Special Funds fromCentral Finance of China in Support of the Development of Local Colleges and University (No. A1- AFD018181Z3961, No. A1-AFD01515A03, No. A1-AFD016151Z3207), Science and Technology Project Scheme of Guangdong Province China (No. 2015B020234008), Natural Science Foundation of Guangdong Province China (No. 2014A030304059), Six Talent Peaks Project in Jiangsu Province (No. 2017-YY-003) and Qing Lan Project of Jiangsu Province.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 2 区 生物
小类 | 2 区 应用化学 2 区 高分子科学 3 区 生化与分子生物学
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 应用化学 2 区 高分子科学
JCR分区：
出版当年[2017]版：
Q1 POLYMER SCIENCE Q1 CHEMISTRY, APPLIED Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CHEMISTRY, APPLIED Q1 POLYMER SCIENCE

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [1]Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, and Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China
共同第一作者：
通讯作者：
通讯机构： [1]Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, and Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China [2]School of pharmaceutical sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China [*1]Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, and Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China
推荐引用方式(GB/T 7714)：
Liang Jian,Wu Yanfang,Yuan Han,et al.Dendrobium officinale polysaccharides attenuate learning and memory disabilities via anti-oxidant and anti-inflammatory actions[J].INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2019,126:414-426.doi:10.1016/j.ijbiomac.2018.12.230.
APA：
Liang, Jian,Wu, Yanfang,Yuan, Han,Yang, Yiqi,Xiong, Qingping...&Hou, Shaozhen.(2019).Dendrobium officinale polysaccharides attenuate learning and memory disabilities via anti-oxidant and anti-inflammatory actions.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,126,
MLA：
Liang, Jian,et al."Dendrobium officinale polysaccharides attenuate learning and memory disabilities via anti-oxidant and anti-inflammatory actions".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 126.(2019):414-426

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