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Therapeutic mechanism exploration of polysaccharides from Dendrobium officinale on unilateral ureteral obstruction operation-induced renal fibrosis based on improving oxidative stress injury mediated by AhR/NOX4 pathway

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资源类型：
Pubmed体系：
作者：
Shi Yingying[1] * ; Zhou Li[3] * ; Zheng Guangzhen[1] * ; Jing Yi[1] ; Zhang Xu[1] ; Yuan Jun[1] ; Zhang Qianghua[1] ; Li Hailun[3] ; Huang Song[4] ; Xie Tian[2,5] ; Xiong Qingping[1] ;
机构： [1]Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai’an, Jiangsu 223003, PR China [2]School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China [3]Department of Nephrology, Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, Jiangsu 223002, PR China [4]School of Pharmaceutical Science, and Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, PR China [5]Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China
出处：
DOI： 10.1016/j.ijbiomac.2023.126920
ISSN：

关键词： Dendrobium officinale polysaccharides Renal fibrosis Oxidative stress injury mediated by AhR/NOX4 pathway

摘要：
Dendrobium officinale polysaccharides (DOP) has been reported to possess remarkable effects on improving renal function, oxidative stress damage and fibrotic diseases. However, the role and mechanism of DOP in preventing and treating renal fibrosis remain unclear. The purpose of this paper was to explore the therapeutic effects and underlying mechanisms of DOP on renal fibrosis. Firstly, renal fibrosis model was induced by unilateral ureteral obstruction operation (UUO) in male BALB/c mice. Subsequently, the anti-renal fibrosis effect of DOP was evaluated. It turned out that DOP significantly attenuated UUO induced renal fibrosis. The beneficial effects of DOP on renal fibrosis were concretely manifested in the relief of clinical symptoms, improvement of renal function, reduction of extracellular matrix collagen aggregation, attenuation of structural damage and inflammation, and decrement of profibrotic factors secretion. Meanwhile, DOP could also alleviate oxidative stress injury and inhibit the AhR/NOX4 pathway proteins expression. Furthermore, multivariate statistical analysis, AhR interference and overexpression experiments showed that the effect of DOP on alleviating renal fibrosis was closely related to the improvement of oxidative stress injury mediated by the AhR/NOX4 pathway. Overall, the data in the present paper indicated that DOP could alleviate renal fibrosis through improving AhR/NOX4 mediated oxidative stress injury.Copyright © 2023. Published by Elsevier B.V.

基金：
Natural Science Foundation of Jiangsu Province of China (No. BK20201477), Project of Science and Technology Development of Traditional Chinese Medicine in Jiangsu Province of China (No. MS2022157 and No. MS2022156), Major Program of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province of China (No. 20KJA360006 and 22KJA360001), General Program of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province of China (No. 20KJB360011), Innovation Training Project for college students in Jiangsu Province of China (No. 202211049065Y, 202211049202XJ and 202211049454YJ), Huai’an City Science and Technology Program Project (No. HAB202211), and Scientific Research Project from Jiangsu Commission of Health of China (No. H2019062).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 化学
小类 | 1 区 高分子科学 2 区 应用化学 2 区 生化与分子生物学
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 应用化学 2 区 高分子科学
第一作者：
第一作者机构： [1]Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai’an, Jiangsu 223003, PR China
共同第一作者：
通讯作者：
通讯机构： [2]School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China [5]Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China
推荐引用方式(GB/T 7714)：
Shi Yingying,Zhou Li,Zheng Guangzhen,et al.Therapeutic mechanism exploration of polysaccharides from Dendrobium officinale on unilateral ureteral obstruction operation-induced renal fibrosis based on improving oxidative stress injury mediated by AhR/NOX4 pathway[J].International journal of biological macromolecules.2023,126920.doi:10.1016/j.ijbiomac.2023.126920.
APA：
Shi Yingying,Zhou Li,Zheng Guangzhen,Jing Yi,Zhang Xu...&Xiong Qingping.(2023).Therapeutic mechanism exploration of polysaccharides from Dendrobium officinale on unilateral ureteral obstruction operation-induced renal fibrosis based on improving oxidative stress injury mediated by AhR/NOX4 pathway.International journal of biological macromolecules,,
MLA：
Shi Yingying,et al."Therapeutic mechanism exploration of polysaccharides from Dendrobium officinale on unilateral ureteral obstruction operation-induced renal fibrosis based on improving oxidative stress injury mediated by AhR/NOX4 pathway".International journal of biological macromolecules .(2023):126920

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