机构：[1]College of Food and Bioengineering, South China University of Technology, Guangzhou 510640, China[2]The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510120, China广东省中医院
Cirsium japonicum DC is listed as a health food in China used for cooling blood and hemostasis. The aim of this study was to identify its active components with anti-inflammation activity. C. japonicum was extract with 70% ethanol, and then loaded on a macroporous resin column chromatography to get five fractions. Results showed that fraction CJ-50 exhibited the best anti-inflammation effect. Six compounds, luteolin-7-O-beta-D-glucuronide (LG), luteolin-7-O-beta-D-glucuronide methyl ester, apigenin-7-O-beta-D-glucuronide (AG), linarin, apigenin-7-O-beta-D-glucuronide methyl ester, and pectolinarin, were isolated and identified from the fraction. The six flavonoid compounds exhibited different degree of anti-inflammatory activity, among which LG and AG showed stronger activity than others. Further research showed that LG can inhibit the NO and pro-inflammatory cytokines production, likely resulting from inhibiting the phosphorylation of JNK. Taken together, these results suggest that LG may be therapeutic candidate for anti-inflammation activity of C. japonicum as well as a dietary complement for health promotion.
基金：
Science and Technology Project of Guangzhou City [201604020150]; Scientific Research Projects of the State Administration of Traditional Chinese Medicine [JDZX2015205]; Guangdong Provincial Science and Technology Department Project [2016A040403105]
第一作者机构：[1]College of Food and Bioengineering, South China University of Technology, Guangzhou 510640, China
通讯作者：
推荐引用方式(GB/T 7714)：
Ma Qin,Jiang Jian-Guo,Zhang Xi-Mei,et al.Identification of luteolin 7-O-β-D-glucuronide from Cirsium japonicum and its anti-inflammatory mechanism[J].JOURNAL OF FUNCTIONAL FOODS.2018,46:521-528.doi:10.1016/j.jff.2018.05.014.
APA：
Ma, Qin,Jiang, Jian-Guo,Zhang, Xi-Mei&Zhu, Wei.(2018).Identification of luteolin 7-O-β-D-glucuronide from Cirsium japonicum and its anti-inflammatory mechanism.JOURNAL OF FUNCTIONAL FOODS,46,
MLA：
Ma, Qin,et al."Identification of luteolin 7-O-β-D-glucuronide from Cirsium japonicum and its anti-inflammatory mechanism".JOURNAL OF FUNCTIONAL FOODS 46.(2018):521-528
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