机构：[1]School of Chinese Meterla Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China[2]State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China[3]The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China[4]Guangdong Province Traditional Chinese Medical Hospital, Guangzhou 510120, China广东省中医院[5]Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China
The dengue virus (DENV) is a vital global public health issue. The 2014 dengue epidemic in Guangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze the phylogenetics of the 2014 dengue strains, the envelope (E) gene sequences from 17 viral strains isolated from 168 dengue patient serum samples were sequenced and a phylogenetic tree was reconstructed. All 17 strains were serotype I strains, including 8 genotype I and 9 genotype V strains. Additionally, 6 genotype I strains that were probably introduced to China from Thailand before 2009 were widely transmitted in the 2013 and 2014 epidemics, and they continued to circulate until 2015, with one affinis strain being found in Singapore. The other 2 genotype I strains were introduced from the Malaya Peninsula in 2014. The transmission source of the 9 genotype V strains was from Malaysia in 2014. DENVs of different serotypes and genotypes co-circulated in the 2014 dengue outbreak in Guangzhou. Moreover, not only had DENV been imported to Guangzhou, but it had also been gradually exported, as the viruses exhibited an enzootic transmission cycle in Guangzhou.
基金：
National Natural Science Foundation of Guangdong Province [S2012030006598]; Science & Technology Planning Project of Guangdong Province of China [2013A020229007]; Innovative Program of the State Key Laboratory of Virology [2016KF001]
第一作者机构：[1]School of Chinese Meterla Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China[2]State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
共同第一作者：
通讯作者：
通讯机构：[1]School of Chinese Meterla Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China[2]State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
推荐引用方式(GB/T 7714)：
Li Geng,Pan Pan,He Qiuyan,et al.Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China[J].VIROLOGICA SINICA.2017,32(1):63-72.doi:10.1007/s12250-016-3872-8.
APA：
Li, Geng,Pan, Pan,He, Qiuyan,Kong, Xiujuan,Wu, Kailang...&Wu, Jianguo.(2017).Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China.VIROLOGICA SINICA,32,(1)
MLA：
Li, Geng,et al."Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China".VIROLOGICA SINICA 32..1(2017):63-72
