机构：[1]Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院[2]Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China[3]Department of Clinical Laboratory Medicine, Zhongshan Hospital of Fudan University, Shanghai, China[4]Department of Laboratory Medicine, Peking University Third Hospital, Beijing, China[5]National Center for Clinical Laboratories, Beijing Hospital, Beijing, China[6]Department of Laboratory Science, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, China广东省中医院[7]Department of Clinical Laboratory Medicine, Xijing Hospital, The Fourth Military Medical University, Xi’an, China
BackgroundReference intervals are important for interpretation of clinical laboratory tests. The platelet (PLT) indices such as the mean platelet volume (MPV) and platelet distribution width (PDW) are newer hematological parameters, which have been recently reported as clinically valuable biomarkers. However, there are not many studies that have estimated the reference intervals for these parameters in healthy Chinese Han adults. ObjectiveThe objectives of this study were to establish reference values of PLT indices [including PLT count, MPV, PDW, platelet-large cell ratio (P-LCR), and plateletcrit (Pct)] for healthy Chinese Han adults. We also aimed to determine the region-based differences of PLT indices in China. MethodsA total of 4,642 volunteers with a mean age of 43 were recruited from six regions of China. PLT indices were performed on Sysmex XE-2100 hematology analyzers, whose traceability was well verified. ResultsThere were significant region-based differences for all PLT indices. Reference people in Chengdu had the lowest mean PLT count and Pct, but the highest MPV, PDW, and P-LCR among the six regions. Therefore, we derived the reference intervals in Chinese Han population excluding Chengdu reference people for PLT indices as PLT count: (127-341) x 10(9)/l; MPV: (9.20-13.30) fl; PDW: 9.90-19.00%; P-LCR: 18.10-52.00%; Pct: 16.00-41.00%. ConclusionsRegion-specific reference intervals are essential as there were statistically significant region-related differences in the PLT parameters. The reference intervals established in this study differed from the existing reference values. Chengdu region may need proper specific reference ranges, which apply to their people, for all PLT parameters.
基金：
Ministry of Health, China Grant number: 2012BAI37B01.
第一作者机构：[1]Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China
共同第一作者：
通讯作者：
通讯机构：[2]Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China[*1]No. 155, Nanjing North Street, Heping District, Shenyang 110001, China
推荐引用方式(GB/T 7714)：
Jiang Hong,Zhao Min,Pan Bai-shen,et al.Investigation on Reference Intervals and Regional Differences of Platelet Indices in Healthy Chinese Han Adults[J].JOURNAL OF CLINICAL LABORATORY ANALYSIS.2015,29(1):21-27.doi:10.1002/jcla.21721.
APA：
Jiang Hong,Zhao Min,Pan Bai-shen,Zhang Jie,Peng Ming-ting...&Shang Hong.(2015).Investigation on Reference Intervals and Regional Differences of Platelet Indices in Healthy Chinese Han Adults.JOURNAL OF CLINICAL LABORATORY ANALYSIS,29,(1)
MLA：
Jiang Hong,et al."Investigation on Reference Intervals and Regional Differences of Platelet Indices in Healthy Chinese Han Adults".JOURNAL OF CLINICAL LABORATORY ANALYSIS 29..1(2015):21-27
