机构：[1]Department of Laboratory Medicine, Peking University Third Hospital, Beijing, China[2]National Center for Clinical Laboratories, Beijing Hospital, Beijing, China[3]Department of Laboratory Science, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, China广东省中医院[4]Department of Laboratory Medicine, West China Hospital, Sichuan University, Sichuan, China四川大学华西医院[5]Department of Clinical Laboratory Medicine, Xijing Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, China[6]Department of Laboratory Medicine, the First Affiliated Hospital of China Medical University, Shenyang, China[7]Department of Clinical Laboratory Medicine, Zhongshan Hospital of Fudan University, Shanghai, China
BackgroundCurrently there are no reference intervals (RIs) of sodium (Na), potassium (K), and chlorine (Cl) on Chinese population. Two kinds of ion-selective electrode (ISE) methods were commonly used to determine K, Na, and Cl levels in China, the difference between these two methods needs to be evaluated. MethodsA total of 4,524 healthy participants (1,916 males and 2,608 females) between 20-79 years old from six cities in China were selected by strict criteria. Serum K, Na, and CL were tested on Roche Modular analyzers in six assigned laboratories. According to EP-9A2, using Roche Modular analyzer (indirect ISE) as comparative method, Olympus AU 5400 analyzer (indirect ISE) and Johnson&Johnson Fusion 5.1 analyzer (direct ISE) were evaluated. ResultsIn Chinese population, the RIs for K, Na, and CL are 3.6-5.2, 136-146, and 99-110 mmol/l, respectively. Compared to the Roche indirect ISE method, Johnson direct ISE method showed a positive bias; and Olympus indirect ISE method just showed a very slight bias. ConclusionThe RIs of K, Na, and Cl of Han Chinese healthy adult population were found to be smaller than those provided by the manufacturer. By a criteria of biological variations for CV, the differences of Na and K between Roche analyzer and Johnson analyzer were not acceptable for clinical application, while the differences of Na, K, and Cl between Roche and Olympus analyzers were acceptable for clinical application.
基金：
Ministry of Health, the People's Republic of China; National key Technologies R&D Program of ChinaNational Key Technology R&D Program [2012BAI37B01]
第一作者机构：[1]Department of Laboratory Medicine, Peking University Third Hospital, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[6]Department of Laboratory Medicine, the First Affiliated Hospital of China Medical University, Shenyang, China[*1]Department of Laboratory Medicine, the First AffiliatedHospital of China Medical University,No. 155 Nanjing North Street, Heping District, Shenyang 110001, China
推荐引用方式(GB/T 7714)：
Jia Keke,Zhang Chuanbao,Huang Xianzhang,et al.Reference Intervals of Serum Sodium, Potassium, and Chlorine in Chinese Han Population and Comparison of Two ISE Methods[J].JOURNAL OF CLINICAL LABORATORY ANALYSIS.2015,29(3):226-234.doi:10.1002/jcla.21755.
APA：
Jia, Keke,Zhang, Chuanbao,Huang, Xianzhang,Wang, Lanlan,Hao, Xiaoke...&Shang, Hong.(2015).Reference Intervals of Serum Sodium, Potassium, and Chlorine in Chinese Han Population and Comparison of Two ISE Methods.JOURNAL OF CLINICAL LABORATORY ANALYSIS,29,(3)
MLA：
Jia, Keke,et al."Reference Intervals of Serum Sodium, Potassium, and Chlorine in Chinese Han Population and Comparison of Two ISE Methods".JOURNAL OF CLINICAL LABORATORY ANALYSIS 29..3(2015):226-234
