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Mitochondrial Fragmentation Is an Important Cellular Event Induced by Ruthenium(II) Polypyridyl Complexes in Osteosarcoma Cells

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收录情况： ◇ SCIE

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机构： [1]Orthopedics Department Guangdong Provincial Hospital of Traditional Chinese Medicine 111 Dade Road, Guangzhou 510120, Guangdong (China) [2]Department of Chemistry, Jinan University 601 Huangpu W Ave, Tianhe, Guangzhou, Guangdong (China)

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关键词： anticancer agents apoptosis mitochondria membrane potential mitochondrial fragmentation ruthenium polypyridyl complexes

摘要：

A series of ruthenium(II) polypyridyl complexes were synthesized and evaluated for their in vitro anticancer activities. The results showed that ruthenium polypyridyl complexes, especially [Ru(bpy)(2)(p-tFPIP)](2+) (2a; bpy=bipyridine, tFPIP=2-(2-trifluoromethane phenyl)imidazole[4,5-f][1,10]phenanthroline), exhibited novel anticancer activity against human cancer cell lines, but with less toxicity to a human normal cell line. The results of flow cytometry and caspase activities analysis indicated that the 2a-induced growth inhibition against MG-63 osteosarcoma cells was mainly caused by mitochondria-mediated apoptosis. DNA fragmentation and nuclear condensation as detected by TUNEL-DAPI co-staining further confirmed 2a-induced apoptotic cell death. Further, fluorescence imaging revealed that ruthenium(II) polypyridyl complexes could target mitochondria to induce mitochondrial fragmentation, accompanied by depletion of mitochondrial membrane potential. Taken together, these findings suggest a potential application of theses ruthenium(II) complexes in the treatment of cancers.

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基金编号： NCET

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出版当年[2013]版：

大类 | 3 区医学

小类 | 3 区药物化学 3 区药学

最新[2025]版：

大类 | 4 区医学

小类 | 3 区药物化学 4 区药学

JCR分区：

出版当年[2012]版：

Q2 PHARMACOLOGY & PHARMACY Q2 CHEMISTRY, MEDICINAL

最新[2023]版：

Q2 CHEMISTRY, MEDICINAL Q2 PHARMACOLOGY & PHARMACY

影响因子： 3.6 最新[2023版] 3.5 最新五年平均 2.835 出版当年[2012版] 3.075 出版当年五年平均 3.151 出版前一年[2011版] 3.046 出版后一年[2013版]

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第一作者机构： [1]Orthopedics Department Guangdong Provincial Hospital of Traditional Chinese Medicine 111 Dade Road, Guangzhou 510120, Guangdong (China)

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