机构：[1]Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China[2]Center for Tuberculosis Control of Guangdong Province, Guangzhou 510630, China[3]Anti-tuberculosis Institute of Jiangmen City, Jiangmen 529020, China[4]The Second People’s Hospital of Zhongshan City, Zhongshan 528447, China[5]GuangDong Provincial Hospital of Chinese Traditional Medicine, 510120, China广东省中医院
To overcome the undesirable side-effects of metronidazole (MTZ), ethylene glycol dimethacrylate is used as the cross-linker, and a series of poly(methacrylic acid) (PMAA) nanogels were prepared to load the MTZ. We investigated the morphology, size, in vitro release property in the simulated gastrointestinal medium, long-term antibacterial performance against Bacteroides fragilis, cytotoxicity, stability and activity of this novel MTZ/PMAA nanogel. The results indicate that the MTZ/PMAA nanogel sustained the release of MTZ in long-term antibacterial activity in the simulated gastrointestinal medium. This MTZ/PMAA nanogel exhibits less cytotoxicity than MTZ alone, suggesting that MTZ/PMAA nanogel is a more useful dosage form than MTZ for mild-to-moderate Clostridium difficile infections. The novel aspects of this study include the synthesis of a nanogel and the three-phase study of the release profile, which might be useful for other researchers in this field. Crown Copyright (C) 2014 Published by Elsevier B.V. All rights reserved.
基金：
National Science and Technology Major Project [2012ZX10004903]; Guang Dong Natural Science FoundationNational Natural Science Foundation of Guangdong Province [WSTJJ20120319130623198210011211]
第一作者机构：[1]Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China[2]Center for Tuberculosis Control of Guangdong Province, Guangzhou 510630, China
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Tao,Chen Liang,Li Haicheng,et al.Design and in vitro evaluation of a novel poly(methacrylic acid)/metronidazole antibacterial nanogel as an oral dosage formZ[J].COLLOIDS AND SURFACES B-BIOINTERFACES.2014,118:65-71.doi:10.1016/j.colsurfb.2014.02.011.
APA：
Chen, Tao,Chen, Liang,Li, Haicheng,Chen, Yuhui,Guo, Huixin...&Zhong, Qiu.(2014).Design and in vitro evaluation of a novel poly(methacrylic acid)/metronidazole antibacterial nanogel as an oral dosage formZ.COLLOIDS AND SURFACES B-BIOINTERFACES,118,
MLA：
Chen, Tao,et al."Design and in vitro evaluation of a novel poly(methacrylic acid)/metronidazole antibacterial nanogel as an oral dosage formZ".COLLOIDS AND SURFACES B-BIOINTERFACES 118.(2014):65-71
