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Lower cytotoxicity, high stability, and long-term antibacterial activity of a poly(methacrylic acid)/isoniazid/rifampin nanogel against multidrug-resistant intestinal Mycobacterium tuberculosis

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ EI

作者：
Chen, Tao[1,2] * ; Li, Qiang[3] * ; Guo, Lina[4] ; Yu, Li[5] ; Li, Zhenyan[6] ; Guo, Huixin[1,2] ; Li, Haicheng[1,2] ; Zhao, Meigui[7] ; Chen, Liang[1,2] ; Chen, Xunxun[1,2] ; Zhong, Qiu[1,2] ; Zhou, Lin[1,2] ; Wu, Ting[8] ;
机构： [1]Center for Tuberculosis Control of Guangdong Province, Guangzhou 510630, PR China [2]Key Laboratory of Translational Medicine of Guangdong, Guangzhou 510630, PR China [3]Department of General Surgery of the First Affiliated Hospital of Jinan University, Guangzhou 510630, PR China [4]Guangdong Provincial Hospital of Chinese Medicine, Guangdong 510120, PR China [5]Light Industry and Food Science, South China University of Technology, Guangzhou 510641, PR China [6]Department of Microbiology and Immunology, Medical College of Jinan University, Guangzhou 510632, PR China [7]Bao'an Chronic Diseases Prevention and Cure Hospital, Shenzhen 518102, PR China [8]Department of Light Chemical Engineering, Guangdong Polytechnic, Foshan 528041, PR China
出处：
DOI： 10.1016/j.msec.2015.08.055
ISSN：

关键词： Nanogel Multidrug-resistant Mycobacterium tuberculosis Intestinal tuberculosis Cytotoxicity Long-term activity

摘要：
To overcome the undesirable side effects and reduce the cytotoxicity of isoniazid (INH) and rifampin (RMP) in the digestive tract, a poly(methacrylic acid) (PMAA) nanogel was developed as a carrier of INH and RMP. This PMAA/INH/RMP nanogel was prepared as a treatment for intestinal tuberculosis caused by multidrug-resistant Mycobacterium tuberculosis (MTB). The morphology, size, and in vitro release properties were evaluated in a simulated gastrointestinal medium, and long-term antibacterial performance, cytotoxicity, stability, and activity of this novel PMAA/INH/RMP nanogel against multidrug-resistant MTB in the intestine were investigated. Our results indicate that the PMAA/INH/RMP nanogel exhibited extended antibacterial activity by virtue of its long-term release of INH and RMP in the simulated gastrointestinal medium. Further, this PMAA/INH/RMP nanogel exhibited lower cytotoxicity than did INH or RMP alone, suggesting that this PMAA/INH/RMP nanogel could be a more useful dosage form than separate doses of INH and RMP for intestinal MTB. The novel aspects of this study include the cytotoxicity study and the three-phase release profile study, which might be useful for other researchers in this field. Crown Copyright (C) 2015 Published by Elsevier B.V. All rights reserved.

基金：
National Science and Technology Key Project [2012ZX10004903, 2013ZX10003001-001-002, 2014ZX10003002-003]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2015A030313864]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类 | 2 区 工程技术
小类 | 3 区 材料科学：生物材料
最新[2025]版：
无
JCR分区：
出版当年[2014]版：
Q3 MATERIALS SCIENCE, BIOMATERIALS
最新[2023]版：
Q1 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

第一作者：
第一作者机构： [1]Center for Tuberculosis Control of Guangdong Province, Guangzhou 510630, PR China [2]Key Laboratory of Translational Medicine of Guangdong, Guangzhou 510630, PR China
共同第一作者：
通讯作者：
通讯机构： [1]Center for Tuberculosis Control of Guangdong Province, Guangzhou 510630, PR China [2]Key Laboratory of Translational Medicine of Guangdong, Guangzhou 510630, PR China
推荐引用方式(GB/T 7714)：
Chen Tao,Li Qiang,Guo Lina,et al.Lower cytotoxicity, high stability, and long-term antibacterial activity of a poly(methacrylic acid)/isoniazid/rifampin nanogel against multidrug-resistant intestinal Mycobacterium tuberculosis[J].MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS.2016,58:659-665.doi:10.1016/j.msec.2015.08.055.
APA：
Chen, Tao,Li, Qiang,Guo, Lina,Yu, Li,Li, Zhenyan...&Wu, Ting.(2016).Lower cytotoxicity, high stability, and long-term antibacterial activity of a poly(methacrylic acid)/isoniazid/rifampin nanogel against multidrug-resistant intestinal Mycobacterium tuberculosis.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,58,
MLA：
Chen, Tao,et al."Lower cytotoxicity, high stability, and long-term antibacterial activity of a poly(methacrylic acid)/isoniazid/rifampin nanogel against multidrug-resistant intestinal Mycobacterium tuberculosis".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 58.(2016):659-665

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