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New sesquiterpenoids with COX-2 inhibitory activity from the medical plant Physalis. alkekengi L. var. franchetii.

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机构: [1]School of Life Sciences, Ludong University, Yantai 264025, China [2]Shandong Provincial Key Laboratory of Quality Safty Monitoring and Risk Assessment for Animal Products, Ji'nan 250022, China [3]Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China [4]Infectious Disease Department, Linyi City People Hospital, Linyi 276000, China [5]Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China
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关键词: Physalis alkekengi L var franchetii Sesquiterpenoids Structural elucidation COX-2 inhibitory activity

摘要:
Phytochemical investigations on Physalis. alkekengi L. var. franchetii, a widespread traditional Chinese medicine, led to the isolation and identification of three new sesquiterpenoids physalisitins A-C (1-3). Their structures were elucidated by NMR and HRESIMS analysis, and their absolute configurations were determined by quantum chemical NMR and ECD calculations, as well as by comparing their optical rotation values with those known analogues. All of the isolated compounds were evaluated for their cyclooxygenase-2 (COX-2) inhibitory activity. Compounds 1-3 dose-dependently inhibited the COX-2 enzyme with IC50 values of 3.22 ± 0.25, 6.35 ± 0.84, and 11.13 ± 1.47 μM, respectively. Copyright © 2020 Elsevier B.V. All rights reserved.

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出版当年[2019]版:
大类 | 3 区 医学
小类 | 3 区 药物化学 3 区 药学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 药物化学 3 区 药学
第一作者:
第一作者机构: [1]School of Life Sciences, Ludong University, Yantai 264025, China [2]Shandong Provincial Key Laboratory of Quality Safty Monitoring and Risk Assessment for Animal Products, Ji'nan 250022, China [5]Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China
通讯作者:
通讯机构: [1]School of Life Sciences, Ludong University, Yantai 264025, China [3]Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China [*2]School of Life Sciences, Ludong University, Yantai 264025, China
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