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Betulinic acid inhibits the migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.

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文献详情

资源类型：
Pubmed体系：
作者：
Li Nan[1] * ; Gong Zhaohui[2] * ; Li Xiaojuan[1] * ; Ma Qingyu[1] ; Wu Mansi[1] ; Liu Dongdong[1] ; Deng Lijuan[1] ; Pan Dongmei[3] ; Liu Qingping[4] ; Wei Zhenquan[4] ; Wang Qiang[4] ; Han Longyin[4] ; Lin Changsong[4,*1] ; Chen Jiaxu[1,*2] ;
机构： [1]Formula-pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong, China [2]Department of Cardiovascular, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China [3]School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China [4]Department of Rheumatology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
出处：
DOI： 10.1016/j.intimp.2018.11.042
ISSN：

关键词： Rheumatoid arthritis Betulinic acid Migration Invasion Fibroblast-like synoviocyte NF-κB

摘要：
The aggressive phenotype displayed by fibroblast-like synoviocytes (FLSs) contributes to cartilage and bone destruction in rheumatoid arthritis (RA). Betulinic acid has been demonstrated to have a positive therapeutic effect on tumor, inflammation and immune disorder, however, the effects of betulinic acid on RA FLSs have not been verified. Therefore, in the present study, we observed the effect of betulinic acid on the migration and invasion of RA FLSs and explored its underlying signal mechanisms. Our results showed that betulinic acid treatment suppressed the migration, invasion and reorganization of the actin cytoskeleton of RA FLSs. In addition, we found that the mRNA expression of IL-1β, IL-6, IL-8 and IL-17A were markedly down-regulated by treatment with betulinic acid in TNF-α-induced RA FLSs. To gain insight into the molecular mechanisms, we evaluated the effect of betulinic acid on NF-κB activation in RA FLSs. The results indicated that betulinic acid treatment reduced the TNF-α-induced activation of NF-κB signal pathway and the NF-κB nuclear accumulation. We also observed that treatment with betulinic acid attenuated synovial inflammation and joint destruction in mice with CIA. Taken together, these results suggest that betulinic acid inhibits the migration and invasion of RA FLSs by blocking NF-κB signal pathway activation. Copyright © 2018 Elsevier B.V. All rights reserved.

基金：
the Guangdong Natural Science Foundation (grant number 2018A0303130112, 2017A030311009), the Fundamental Research Funds for the Central Universities (grant number 11618335) and the National Natural Science Foundation of China (grant number 81774262).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 3 区 医学
小类 | 3 区 免疫学 3 区 药学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 药学 3 区 免疫学
第一作者：
第一作者机构： [1]Formula-pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong, China
共同第一作者：
通讯作者：
通讯机构： [1]Formula-pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong, China [4]Department of Rheumatology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China [*1]Department of Rheumatology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, No. 16 Jichang Road, Guangzhou, Guangdong 510405, China [*2]Formula-pattern Research Center, School of Traditional Chinese Medicine, Jinan University, No.601, West Huangpu Avenue, Guangzhou, Guangdong 510632, China
推荐引用方式(GB/T 7714)：
Li Nan,Gong Zhaohui,Li Xiaojuan,et al.Betulinic acid inhibits the migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.[J].International immunopharmacology.2019,67:186-193.doi:10.1016/j.intimp.2018.11.042.
APA：
Li Nan,Gong Zhaohui,Li Xiaojuan,Ma Qingyu,Wu Mansi...&Chen Jiaxu.(2019).Betulinic acid inhibits the migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis..International immunopharmacology,67,
MLA：
Li Nan,et al."Betulinic acid inhibits the migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.".International immunopharmacology 67.(2019):186-193

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