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Role of small ubiquitin-like modifier proteins-1 (SUMO-1) in regulating migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Lao Minxi[1] * ; Zhan Zhongping[1] * ; Li Nan[2] * ; Xu Siqi[1] ; Shi Maohua[1,3] ; Zou Yaoyao[4] ; Huang Mingcheng[5] ; Zeng Shan[6] ; Liang Liuqin[1] ; Xu Hanshi[1,*1] ;
机构： [1]Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China [2]School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong, China [3]Department of Rheumatology, The First People's Hospital of Foshan, Foshan, Guangdong, China [4]Department of Rheumatology, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China [5]Department of Hematology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China [6]Department of Rheumatology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China
出处：
DOI： 10.1016/j.yexcr.2018.12.011
ISSN：

关键词： Rheumatoid arthritis Small ubiquitin-like modifier Inflammation Migration Fibroblast-like synoviocytes

摘要：
Rheumatoid arthritis (RA) is featured by erosive cartilage and bone destruction. The enhancing aggressive property of fibroblast-like synoviocytes (FLSs) plays a critical role in this process. Small ubiquitin-like modifier (SUMO) proteins, including SUMO-1, SUMO-2, SUMO-3 and SUMO-4, participate in regulating many cellular events such as survival, migration and signal transduction in some cell lines. However, their roles in the pathogenesis of RA are not well established. Therefore, we evaluated the role of SUMO proteins in RA FLSs migration and invasion. We found that expression of both SUMO-1 and SUMO-2 was elevated in FLSs and synovial tissues (STs) from patients with RA. SUMO-1 suppression by small interference RNA (siRNA) reduced migration and invasion as well as MMP-1 and MMP-3 expression in RA FLSs. We also demonstrated that SUMO-1 regulated lamellipodium formation during cell migration. To explore further into molecular mechanisms, we evaluated the effect of SUMO-1 knockdown on the activation of Rac1/PAK1, a critical signaling pathway that controls cell motility. Our results indicated that SUMO-1-mediated SUMOylation controlled Rac1 activation and modulated downstream PAK1 activity. Inhibition of Rac1 or PAK1 also decreased migration and invasion of RA FLSs. Our findings suggest that SUMO-1 suppression could be protective against joint destruction in RA by inhibiting aggressive behavior of RA FLSs. Copyright © 2018 Elsevier Inc. All rights reserved.

基金：
the National Natural Science Foundation of China (81601403, 81603435, 81671591, 81871275), Guangdong Technology Project (2016A020215043) and grants from Natural Science Foundation of Guangdong Province (2018A0303130294).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 2 区 医学
小类 | 3 区 细胞生物学 3 区 肿瘤学
最新[2025]版：
大类 | 3 区 生物学
小类 | 4 区 细胞生物学 4 区 肿瘤学
JCR分区：
出版当年[2017]版：
Q2 ONCOLOGY Q3 CELL BIOLOGY
最新[2023]版：
Q2 ONCOLOGY Q3 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [1]Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China [*1]Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Road 2, Guangzhou, Guangdong 510080, China.
推荐引用方式(GB/T 7714)：
Lao Minxi,Zhan Zhongping,Li Nan,et al.Role of small ubiquitin-like modifier proteins-1 (SUMO-1) in regulating migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.[J].EXPERIMENTAL CELL RESEARCH.2019,375(1):52-61.doi:10.1016/j.yexcr.2018.12.011.
APA：
Lao Minxi,Zhan Zhongping,Li Nan,Xu Siqi,Shi Maohua...&Xu Hanshi.(2019).Role of small ubiquitin-like modifier proteins-1 (SUMO-1) in regulating migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis..EXPERIMENTAL CELL RESEARCH,375,(1)
MLA：
Lao Minxi,et al."Role of small ubiquitin-like modifier proteins-1 (SUMO-1) in regulating migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.".EXPERIMENTAL CELL RESEARCH 375..1(2019):52-61

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