机构：[1]Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China[2]Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China[3]Department of Radiotherapy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China[4]Department of Emergency, Zhumadian Second Hospital of Traditional Chinese Medicine, Zhumadian 463000, China[5]Department of Traditional Chinese Medicine, Scientific Research Platform, The Second School of Clinical Medicine, Guangdong Medical University, Dongguan 523808, China
Resistance to radiotherapy remains a severe obstacle in the treatment of high-risk colorectal
cancer patients. Recent studies have indicated that proteasome activator complex
subunit 3 (PSME3) participates in the development and progression of various human malignancies
and is proposed to play a role in tumor radioresistance. However, the impact of
PSME3 on radioresistance of colorectal cancer has been largely unknown. In the present
study, the enhanced expression of PSME3 was observed in colorectal cancer cells and
tissue. Upregulation of PSME3 was significantly implicated in lymph node state, lymphovascular
invasion, and Dukes’ stage. Furthermore, high PSME3 expression was closely
linked to poorer overall and progression-free survival in patients with colorectal cancer.
The study further demonstrated that the proliferative, invasive and migratory potential of
colorectal cancer cells was effectively inhibited in vitro after silencing PSME3. Our results
verified that knockdown of PSME3 probably triggered cell cycle arrest at the G2/M phase by
downregulation of cyclinB1 and CDK1, thereby enhancing the radiosensitivity of colorectal
cancer cells. These data illustrated that PSME3 is a promising biomarker predictive of
colorectal cancer prognosis and silencing of PSME3 may provide with a new approach
for sensitizing the radiotherapy in colorectal cancer.
基金：
This study was supported by the National Natural Science
Foundation of China (grant no. 81272763 and 81672466), the
Natural Science Foundation of Guangdong Province (grant no.
2014A030313286 and 2017A030313550) And “Group-type”
Special Support Project for Education Talents in Universities
(grant no. G619080438 and 4SG19044G).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验
第一作者：
第一作者机构：[1]Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China[2]Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China[3]Department of Radiotherapy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
通讯作者：
通讯机构：[1]Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China[2]Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
推荐引用方式(GB/T 7714)：
Wen Song,Cuiping Guo,Jianxiong Chen,et al.Silencing PSME3 induces colorectal cancer radiosensitivity by downregulating the expression of cyclin B1 and CKD1.[J].Experimental biology and medicine (Maywood, N.J.).2019,244(16):1409-1418.doi:10.1177/1535370219883408.
APA：
Wen Song,Cuiping Guo,Jianxiong Chen,Shiyu Duan,Yukun Hu...&Jun Zhou.(2019).Silencing PSME3 induces colorectal cancer radiosensitivity by downregulating the expression of cyclin B1 and CKD1..Experimental biology and medicine (Maywood, N.J.),244,(16)
MLA：
Wen Song,et al."Silencing PSME3 induces colorectal cancer radiosensitivity by downregulating the expression of cyclin B1 and CKD1.".Experimental biology and medicine (Maywood, N.J.) 244..16(2019):1409-1418
