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Inhibitory Effect of MicroRNA-107 on Osteosarcoma Malignancy Through Regulation of Wnt/β-catenin Signaling in Vitro.

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机构： [a]Spine Department, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong , P.R. China [b]Spine Department, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong , P.R. China

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关键词： miR-107 β-catenin Osteosarcoma Cell proliferation Invasion Migration

摘要：

We showed that miR-107 expression was decreased in osteosarcoma (OS) tissues and cell lines. miR-107 mimic significantly decreased OS cell proliferation and inhibited invasion and migration of OS cells. Inhibition of miR-107 expression notably promoted proliferation, invasion and migration of OS cells. In addition, miR-107 mimic inhibited EMT biomarkers and significantly increased apoptosis. miR-107 mimic significantly decreased the protein expression of β-catenin, Cyclin D1, and c-Myc, whereas increased GSK-3β protein expression. miR-107 mimic markedly reduced the luciferase activity of 3'UTR of β-catenin. Overexpression of β-catenin inhibited miR-107 mimic-induced decrease of cell proliferation, invasion and migration ability, and increase of apoptosis.

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出版当年[2017]版：

大类 | 3 区医学

小类 | 4 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

第一作者：

第一作者机构： [a]Spine Department, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong , P.R. China

通讯作者：

通讯机构： [a]Spine Department, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong , P.R. China [*1]Spine Department, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong 528000, P.R. China.

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