机构：[1]Guangdong Key Laboratory for Genome Stability & Disease Prevention, Department of Pharmacology and Carson International Cancer Research Centre, Shenzhen University School of Medicine, Shenzhen 518060, China深圳市康宁医院深圳医学信息中心[2]Zhejiang Key Laboratory of Gastro-Intestinal Pathophysiology, Zhejiang Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, Hangzhou 310006, China
Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted Wingless-type (WNT) ligands in the WNT signaling pathway. Functionally, FZDs play crucial roles in regulating cell polarity, embryonic development, cell proliferation, formation of neural synapses, and many other processes in developing and adult organisms. In this review, we will introduce the basic structural features and review the biological function and mechanism of FZDs in the progression of human cancers, followed by an analysis of clinical relevance and therapeutic potential of FZDs. We will focus on the development of antibody-based and small molecule inhibitor-based therapeutic strategies by targeting FZDs for human cancers.
基金：
This work was supported by the National Key R&D program of China (2017YFA0503900
and 2016YFC0904600), the National Natural Science Foundation of China (81772957),the Science and
Technology Foundation of Shenzhen (KQTD20140630100658078), and the Shenzhen Peacock Program
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区化学
小类|3 区生化与分子生物学3 区化学综合
最新[2025]版：
大类|3 区生物学
小类|3 区生化与分子生物学3 区化学：综合
第一作者：
第一作者机构：[1]Guangdong Key Laboratory for Genome Stability & Disease Prevention, Department of Pharmacology and Carson International Cancer Research Centre, Shenzhen University School of Medicine, Shenzhen 518060, China
通讯作者：
推荐引用方式(GB/T 7714)：
Zeng Chui-Mian,Chen Zhe,Fu Li.Frizzled Receptors as Potential Therapeutic Targets in Human Cancers.[J].International journal of molecular sciences.2018,19(5):doi:10.3390/ijms19051543.
APA：
Zeng Chui-Mian,Chen Zhe&Fu Li.(2018).Frizzled Receptors as Potential Therapeutic Targets in Human Cancers..International journal of molecular sciences,19,(5)
MLA：
Zeng Chui-Mian,et al."Frizzled Receptors as Potential Therapeutic Targets in Human Cancers.".International journal of molecular sciences 19..5(2018)
