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Cytoprotective effects of paeoniflorin are associated with translocator protein 18 kDa.

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机构： [a]Pharmaceutical Department of The First Affiliated Hospital of Guangdong Pharmaceutical University, Clinical Pharmacy Department of Guangdong Pharmaceutical University, Guangzhou 510080, PR China [b]Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China [c]Pharmacy Department of General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, PR China [d]Tuina and Pain Management Department, Shenzhen LongGang Hospital of Traditional Chinese Medicine (Beijing University of Chinese Medicine Shenzhen Hospital), Shenzhen 518172, PR China [e]College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, PR China

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关键词： Cytoprotection Neurosteroids PF TSPO

摘要：

Paeoniflorin (PF) is one of the important active components in peony that are known to produce the neuroprotective effects. However, the involved cytoprotective factors on brain astrocytes are remain unclear. Translocator protein 18 kDa (TSPO) and its downstream neurosteroids biosynthesis play a significant role in cytoprotection. Based on these, the role of TSPO and neurosteroids biosynthesis in the cytoprotective effects of PF is evaluated. The astrocyte cells were cultured and AC-5216 (TSPO ligand) was selected as the positive control drug. The cytoprotective effects of PF and the levels of neurosteroids were quantified by water-soluble tetrazolium assay and enzyme linked immunosorbent assay, respectively. The cytoprotective activities of PF were relevant to neurosteroids (e.g. progsterone and allopregnanolone) biosynthesis, while these effects were totally blocked by PK11195, trilostane and finasteride, respectively. In summary, the cytoprotective effects of PF maybe mediated by TSPO and neurosteroids biosynthesis. The findings may provide the new insights into the cytoprotective effects of PF. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

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出版当年[2017]版：

大类 | 3 区医学

小类 | 3 区药学 4 区医学：研究与实验

最新[2025]版：

大类 | 2 区医学

小类 | 2 区医学：研究与实验 2 区药学

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出版当年[2016]版：

Q2 MEDICINE, RESEARCH & EXPERIMENTAL Q2 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q1 PHARMACOLOGY & PHARMACY

影响因子： 6.9 最新[2023版] 6.8 最新五年平均 2.759 出版当年[2016版] 2.534 出版当年五年平均 2.326 出版前一年[2015版] 3.457 出版后一年[2017版]

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第一作者机构： [a]Pharmaceutical Department of The First Affiliated Hospital of Guangdong Pharmaceutical University, Clinical Pharmacy Department of Guangdong Pharmaceutical University, Guangzhou 510080, PR China [b]Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China

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Cytoprotective effects of paeoniflorin are associated with translocator protein 18 kDa.

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Cytoprotective effects of paeoniflorin are associated with translocator protein 18 kDa.