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Paeoniflorin elicits the anti-proliferative effects on glioma cell via targeting translocator protein 18 KDa.

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机构： [1]Shunde Hospital of Guangzhou University of TCM, Foshan, Guangdong, 528300, China [2]School of Traditional Chinese Medicine, Southern Medical University Guangzhou, Guangdong, 510515, China [3]Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong, 510515, China [4]The Fifth Affiliated Hospital of Southern Medical University, China Guangzhou, Guangdong, 510900, China

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关键词： Paeoniflorin TSPO Glioma Neurosteroids PK11195

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As a natural compound isolated from Paeoniae radix, Paeoniflorin (PF) has been shown the antitumor effects in various types of human cancers including glioma, which is one of the serious tumors in central nervous system. Translocator protein 18 KDa (TSPO) has been shown to be relevant to the glioma aetiology. However, the regulation of PF in TSPO and neurosteriods biosynthesis on glioma is still unclear. In the present study, the glioma cell (U87 and U251) were cultured and used to quantify the bindings of PF on TSPO. Results indicated that there was not significant different between IC50 of PF and TSPO ligand PK11195. Moreover, PF exerted the anti-proliferative effects in glioma cell with a dose dependent inhibition from 12.5 to 100 μM in vitro. Consistent with the effects of PK11195, lowered levels on progesterone, allopregnanolone, as well as TSPO mRNA were induced by PF (25 and 50 μM). Furthermore, a xenograft mouse model with U87 cell-derived was significant inhibited by PF treatment, as well as the PK11195 administration. These results demonstrate that PF exerts its antitumor effects associated with the TSPO and neurosteroids biosynthesis in glioma cells could be a promising therapeutic agent for glioma therapy. Copyright © 2020 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

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出版当年[2020]版：

大类 | 3 区医学

小类 | 3 区药学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区药学

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第一作者机构： [1]Shunde Hospital of Guangzhou University of TCM, Foshan, Guangdong, 528300, China [2]School of Traditional Chinese Medicine, Southern Medical University Guangzhou, Guangdong, 510515, China

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