机构：[1]Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China[2]Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China[3]Department of anesthesia, Fifth Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China[4]Department of Anesthesia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China[5]Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Science, Guangzhou, Guangdong, China广东省人民医院[6]Department of Anesthesia, Huarui Hospital, Southern Medical University, Guangzhou, Guangdong, China[7]The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China
Anesthetics are unavoidable to colorectal cancer (CRC) patients who underwent surgical treatment. Thus, the molecular mechanisms underlying the role of the intravenous anesthetics in CRC metastasis are still unclear. In this study, the effects of intravenous anesthetics, such as propofol, etomidate and dexmedetomidine, on cell migration were determined. The migration of CRC cells was inhibited by propofol in vitro, but not in vivo. Etomidate, however, promoted the migration of CRC cells both in vitro and in vivo. Epithelial-mesenchymal transition (EMT) mediated the promotive effect of propofol and etomidate on the migration of CRC cells through PI3K/AKT signaling pathway. Dexmedetomidine alone or in combination with propofol or etomidate had minor effect on the migration of CRC cells. These findings indicate that propofol inhibites CRC cell migration in vitro. Etomidate playes a role for prompting CRC metastasis progression by activating (PI3K)/AKT signaling and inducing EMT. It provides an important hint for the clinical application of these anesthetics.
基金：
This work was supported by the National Natural Science Foundation of China (Nos. 81572813, 81272762, 81201635, 81302758), Guangdong Natural Science Funds for Distinguished Young Scholar (S20120011334), Guangdong Natural Science Foundation (S2012040006418, S2013010014254, 2014A030313490, 2015A030313274), Science and Technology Program of Guangzhou (1563000235).
第一作者机构：[1]Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China[2]Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China[2]Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China
推荐引用方式(GB/T 7714)：
Fengliu Deng,Mingwen Ouyang,Xiaofei Wang,et al.Differential role of intravenous anesthetics in colorectal cancer progression: implications for clinical application.[J].ONCOTARGET.2016,7(47):77087-77095.doi:10.18632/oncotarget.12800.
APA：
Fengliu Deng,Mingwen Ouyang,Xiaofei Wang,Xueqing Yao,Yeming Chen...&Liang Zhao.(2016).Differential role of intravenous anesthetics in colorectal cancer progression: implications for clinical application..ONCOTARGET,7,(47)
MLA：
Fengliu Deng,et al."Differential role of intravenous anesthetics in colorectal cancer progression: implications for clinical application.".ONCOTARGET 7..47(2016):77087-77095
医学