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Gardenamide A attenuated cell apoptosis induced by serum deprivation insult via the ERK1/2 and PI3K/AKT signaling pathways.

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资源类型：
Pubmed体系：
作者：
Wang R[1] * ; Yang J[2] * ; Peng L[2] ; Zhao J[2] ; Mu N[3] ; Huang J[5] ; Lazarovici P[6] ; Chen H[2,4,*1] ; Zheng W[1,*1] ;
机构： [1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, PR China [2]Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China [3]Guangzhou Brain Hospital, 36 Mingxin Road, Liwan District,Guangzhou 510370, PR China [4]Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangzhou 510632, PR China [5]Family Planning Service Center of Dongguan, Dongguan 523079, PR China [6]School of Pharmacy Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
出处：
DOI： 10.1016/j.neuroscience.2014.11.056
ISSN：

关键词： Gardenamide A serum deprivation cell apoptosis Akt ERK1/2 ROS

摘要：
Gardenamide A (GA) is a stable genipin derivative with neuroprotective properties. It rescued pheochromocytoma cell (PC12) sympathetic cultures and retinal neuronal cells from apoptosis insult induced by serum deprivation. GA attenuated the accumulation of intracellular reactive oxygen species (ROS) and the loss of mitochondrial membrane potential. Western blotting with specific phospho-antibodies indicated that GA increased the phosphorylation of both the protein kinase B (Akt) and the extracellular signal-regulated kinase (ERK1/2) in PC12 cells. The GA neuroprotective effect was inhibited by either the specific phosphoinositide 3-kinase (PI3K) inhibitor LY294002 or the mitogen-activated protein kinase (MAPK) pathway inhibitor PD98059. These results propose that the neuroprotective effect of GA on PC12 neuronal cell cultures was mediated through both the PI3K/Akt and ERK1/2 signaling pathways. Therefore, GA may serve as a pharmacological tool to investigate neuroprotective mechanisms of neurons afflicted by different insults. Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

基金：
National Natural Science Foundation of China (Nos. 81172982, 30670652, 30970935, and 31371088), the Guangdong Provincial Project of Science and Technology (Nos.2010A030100006 and 2011B050200005), and the Director’s Fund of State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类 | 3 区 医学
小类 | 3 区 神经科学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 神经科学
第一作者：
第一作者机构： [1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, PR China
共同第一作者：
通讯作者：
通讯机构： [1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, PR China [2]Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China [4]Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangzhou 510632, PR China [*1]College of Pharmacy, Jinan University, Huangpu Avenue West 601, Guangzhou 510632, PR China.
推荐引用方式(GB/T 7714)：
Wang R,Yang J,Peng L,et al.Gardenamide A attenuated cell apoptosis induced by serum deprivation insult via the ERK1/2 and PI3K/AKT signaling pathways.[J].Neuroscience.2015,286:242-50.doi:10.1016/j.neuroscience.2014.11.056.
APA：
Wang R,Yang J,Peng L,Zhao J,Mu N...&Zheng W.(2015).Gardenamide A attenuated cell apoptosis induced by serum deprivation insult via the ERK1/2 and PI3K/AKT signaling pathways..Neuroscience,286,
MLA：
Wang R,et al."Gardenamide A attenuated cell apoptosis induced by serum deprivation insult via the ERK1/2 and PI3K/AKT signaling pathways.".Neuroscience 286.(2015):242-50

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