MicroRNAs (miRNAs) can serve as tumor suppressors and might provide an efficient strategy for annihilating tumor cells. Nevertheless, the potential role of miR-325 in hepatocellular carcinoma (HCC) is still unknown.
Using RT-PCR, immunoblots invasion assays and bioinformatics strategies, we investigated the potential role of miR-325 in HCC.
We showed that miR-325 was decreased and HMGB1 was increased in 99 patients with hepatocellular carcinoma. MiR-325 inhibition promoted cell invasion and proliferation, while miR-325 upregulation inhibited cell invasion and proliferation by using transwell and CCK8 assays. We further showed that HMGB1 might be a direct target of miR-325 and is negatively regulated by miR-325. Down-regulation of miR-325 predicts poor prognosis for HCC patients.
These findings implied that miR-325 regulates cell invasion and proliferation via targeting HMGB1 and may be a potential prognostic marker for HCC.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4655707031717989.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|4 区医学
小类|4 区病理学
最新[2025]版：
大类|3 区医学
小类|3 区病理学
第一作者：
第一作者机构：[1]Department of Chemotherapy, Zhongshan People’s Hospital, Zhongshan, Guangdong 528400, China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Huifen,Huang Weihua,Luo Rongcheng.The microRNA-325 inhibits hepatocellular carcinoma progression by targeting high mobility group box 1.[J].Diagnostic pathology.2015,10:117.doi:10.1186/s13000-015-0323-z.
APA：
Li Huifen,Huang Weihua&Luo Rongcheng.(2015).The microRNA-325 inhibits hepatocellular carcinoma progression by targeting high mobility group box 1..Diagnostic pathology,10,
MLA：
Li Huifen,et al."The microRNA-325 inhibits hepatocellular carcinoma progression by targeting high mobility group box 1.".Diagnostic pathology 10.(2015):117
