机构：[1]Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan Province, China[2]Department of Psychiatry, Brain Hospital of Hunan Province, Changsha, Hunan Province, China[3]Laboratory of Ethnopharmacology, Institute of Integrated Traditional Medicine and Western Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China[4]Guangzhou Brain Hospital, Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong Province, China
Shuganjieyu capsule has been approved for clinical treatment by the State Food and Drug Ad-ministration of China since 2008. In the clinic, Shuganjieyu capsule is often used to treat mild to moderate depression. In the rat model of depression established in this study, Shuganjieyu capsule was administered intragastrically daily before stress. Behavioral results confirmed that depressive symptoms lessened after treatment with high-dose (150 mg/kg) Shuganjieyu capsule. Immunohistochemistry results showed that high-dose Shuganjieyu capsule significantly increased phosphorylation levels of phosphorylation cyclic adenosine monophosphate response element binding protein and brain-derived neurotrophic factor expression in the medial prefrontal cortex and hippocampal CA3 area. Overall, our results suggest that in rats, Shuganjieyu capsule effec-tively reverses depressive-like behaviors by increasing expression levels of neurotrophic factors in the brain.
基金：
the National Natural Science Foundation of China, No.
81071093, 81171268
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2013]版：
大类|4 区医学
小类|4 区细胞生物学4 区神经科学
最新[2025]版：
大类|2 区医学
小类|2 区细胞生物学2 区神经科学
第一作者：
第一作者机构：[1]Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan Province, China[2]Department of Psychiatry, Brain Hospital of Hunan Province, Changsha, Hunan Province, China
通讯作者：
通讯机构：[1]Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan Province, China[*1]Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha 410011, Hunan Province, China
推荐引用方式(GB/T 7714)：
Jinhua Fu,Yingjin Zhang,Renrong Wu,et al.Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression.[J].Neural Regeneration Research.2014,9(5):489-97.doi:10.4103/1673-5374.130067.
APA：
Jinhua Fu,Yingjin Zhang,Renrong Wu,Yingjun Zheng,Xianghui Zhang...&Yong Liu.(2014).Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression..Neural Regeneration Research,9,(5)
MLA：
Jinhua Fu,et al."Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression.".Neural Regeneration Research 9..5(2014):489-97
