Ischemic stroke subtyping was not only highly valuable for effective intervention and treatment, but also important to the prognosis of ischemic stroke. The manual adjudication of disease classification was time-consuming, error-prone, and limits scaling to large datasets. In this study, an integrated machine learning approach was used to classify the subtype of ischemic stroke on The International Stroke Trial (IST) dataset. We considered the common problems of feature selection and prediction in medical datasets. Firstly, the importances of features were ranked by the Shapiro-Wilk algorithm and Pearson correlations between features were analyzed. Then, we used Recursive Feature Elimination with Cross-Validation (RFECV), which incorporated linear SVC, Random-Forest-Classifier, Extra-Trees-Classifier, AdaBoost-Classifier, and Multinomial-Naive-Bayes-Classifier as estimator respectively, to select robust features important to ischemic stroke subtyping. Furthermore, the importances of selected features were determined by Extra-Trees-Classifier. Finally, the selected features were used by Extra-Trees-Classifier and a simple deep learning model to classify the ischemic stroke subtype on IST dataset. It was suggested that the described method could classify ischemic stroke subtype accurately. And the result showed that the machine learning approaches outperformed human professionals.