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Exercise training restores IGFIR survival signaling in d-galactose induced-aging rats to suppress cardiac apoptosis.

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机构： [a]School of Chinese Medicine, College of Chinese Medicine, China Medical University, 40402 Taichung, Taiwan [b]Department of Chinese Medicine, China Medical University Beigang Hospital, Yunlin County 65152, Taiwan [c]Department of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan [d]Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan [e]Integration Center of Traditional Chinese and Modern Medicine, HualienTzu Chi Hospital, Hualien 97002, Taiwan [f]Department of Chinese Medicine, Hualien Tzu Chi Hospital, Hualien 97002, Taiwan [g]School of Post Baccalaureate Chinese Medicine, College of Medicine, Tzu Chi University, Hualien 97004, Taiwan [h]Department of Psychology, Asia University, Taichung, Taiwan [i]Department of Nursing, Meiho University, Pingtung, Taiwan [j]Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, 89 Guhuai Road, Jining, Shandong 272029, China [k]Department of Cardiology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan 511518, Guangdong, China [l]Department of Biotechnology, Asia University, Taichung, Taiwan [m]Department of Medical Research, China Medical University Hospital, Taichung, Taiwan [n]Holistic Education Center, Tzu Chi University of Science and Technology, Hualien, Taiwan

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关键词： Senescence Cardiac apoptosis Fibrosis Cell survival Aging

摘要：

Insulin-like growth factor-I receptor (IGF1R) mediated survival signaling is a crucial mechanism for cellular endurance and a potential indicator of recuperation in deteriorating hearts. This study evaluates the impact of long-term exercise training in enhancing cardiac survival mechanism in D-galactose-induced toxicity associated aging rats. Forty-eight male SD-rats were segregated into 4 groups (n=9) and were named as control, exercise training groups, aging group and aging group with exercise training. Aging was induced by intraperitoneal (IP) D-galactose (150 mL/kg) injection for 8 weeks and for exercise training, the rats were left to swim in warm water for 60 min every day and 5 times/week. Western blotting of proteins from the left ventricles was performed to identify the modulations in the survival signaling. Tissue sections were analyzed to determine the extent of fibrosis and apoptosis. Western-blot analysis performed on the excised left ventricles (LV) showed that proteins of the cardiac survival pathway including IGF1R and Akt and the pro-survival Bcl-2 showed significant decrease in the aging group, whereas the levels were restored in the aging rats subjected to exercise training. In addition, aging groups showed increased interstitial space and collagen accumulation. Further, TUNEL assay showed higher number of apoptotic cells in the LV of aging group, which was correlated with increase in the proteins involved in FAS-FADD-dependent apoptosis. However, these aging associated effects were ameliorated upon exercise training in the D-galactose-induced aging rats that showed elevated IGF1R/Akt signaling. The results suggest that IGFIR survival signaling cascadeis elevated in following long-term exercise training and thereby provide cardio-protective benefits in D-galactose induced aging rats. © 2020 The Authors. Published by Elsevier B.V. on behalf of Cairo University.

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出版当年[2020]版：

大类 | 2 区综合性期刊

小类 | 2 区综合性期刊

最新[2025]版：

大类 | 1 区

综合性期刊

小类 | 1 区综合性期刊

第一作者：

第一作者机构： [a]School of Chinese Medicine, College of Chinese Medicine, China Medical University, 40402 Taichung, Taiwan [b]Department of Chinese Medicine, China Medical University Beigang Hospital, Yunlin County 65152, Taiwan

通讯作者：

通讯机构： [a]School of Chinese Medicine, College of Chinese Medicine, China Medical University, 40402 Taichung, Taiwan [d]Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan [l]Department of Biotechnology, Asia University, Taichung, Taiwan [m]Department of Medical Research, China Medical University Hospital, Taichung, Taiwan [n]Holistic Education Center, Tzu Chi University of Science and Technology, Hualien, Taiwan [*a]Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.

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Exercise training restores IGFIR survival signaling in d-galactose induced-aging rats to suppress cardiac apoptosis.

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