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Novel pectin-like polysaccharide from Panax notoginseng attenuates renal tubular cells fibrogenesis induced by TGF-β.

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资源类型：
Pubmed体系：
作者：
Huang Chunfan[1,2,7] * ; Jing Xiaoqi[2,3] * ; Wu Qianhu[1,7,*1] ; Ding Kan[1,2,4,5,6,*1] ;
机构： [1]College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu Province 210029, China [2]Glycochemistry and Glycobiology Lab, Carbohydrate-based Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong [3]Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China [4]University of Chinese Academy of Science, No.19A Yuquan Road, Beijing 100049, China [5]Henan Polysaccharide Research Center, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China [6]Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Science, SSIP Healthcare and Medicine Demonstration Zone, [7]Zhenjiang the Third People’s Hospital, 300 Daijiamen Avenue, Zhenjiang, Jiangsu Province 212021, China
出处：
DOI： 10.1016/j.carbpol.2021.118772
ISSN：

关键词： Panax notoginseng Polysaccharide Renal fibrosis Epithelial-mesenchymal transition Pectin

摘要：
Renal fibrosis is the final common result of a variety of progressive injuries leading to chronic renal failure. However, there are no effective clinical available drugs for the treatment. Notoginsenoside from Panax notoginseng could ameliorate renal fibrosis. We hypothesized that polysaccharide from this herb might have similar bioactivity. Here, we elucidated structure of a novel pectin-like polysaccharide designed SQD4S2 with a netty antenna backbone of glucogalacturonan substituted by glucoarabinan, glucurogalactan and galactose residues from this herb. Interestingly, SQD4S2 could reverse the morphological changes of human renal tubular HK-2 cells induced by TGF-β. Mechanism study suggested that this bioactivity might associate with N-cadherin (CDH2), Snail (SNAI1), Slug (SNAI2) depression and E-cadherin (CDH1) enhancement. In addition, SQD4S2 could impede critical fibrogenesis associated molecules such as α-SMA, fibronectin, vimentin, COL1A1, COL3A1, FN1 and ACTA2 expression induced by TGF-β in HK-2 cells. Current findings outline a novel leading polysaccharide for against renal fibrosis new drug development.Copyright © 2021. Published by Elsevier Ltd.

基金：
This work is funded by National Key Research and Development Program of China, Ministry of Science and Technology, China (Grant number 2019YFC1711-000), Key New Drug Creation and Manufacturing Program (Grant number 2019ZX09735001) and Shanghai Municipal Science and Technology Major Project.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 1 区 化学
小类 | 1 区 应用化学 1 区 有机化学 1 区 高分子科学
最新[2025]版：
大类 | 1 区 化学
小类 | 1 区 应用化学 1 区 有机化学 1 区 高分子科学
第一作者：
第一作者机构： [1]College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu Province 210029, China [2]Glycochemistry and Glycobiology Lab, Carbohydrate-based Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong [7]Zhenjiang the Third People’s Hospital, 300 Daijiamen Avenue, Zhenjiang, Jiangsu Province 212021, China
共同第一作者：
通讯作者：
通讯机构： [1]College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu Province 210029, China [2]Glycochemistry and Glycobiology Lab, Carbohydrate-based Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong [4]University of Chinese Academy of Science, No.19A Yuquan Road, Beijing 100049, China [5]Henan Polysaccharide Research Center, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China [6]Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Science, SSIP Healthcare and Medicine Demonstration Zone, [7]Zhenjiang the Third People’s Hospital, 300 Daijiamen Avenue, Zhenjiang, Jiangsu Province 212021, China [*1]College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu Province 210029, China
推荐引用方式(GB/T 7714)：
Huang Chunfan,Jing Xiaoqi,Wu Qianhu,et al.Novel pectin-like polysaccharide from Panax notoginseng attenuates renal tubular cells fibrogenesis induced by TGF-β.[J].Carbohydrate polymers.2022,276:118772.doi:10.1016/j.carbpol.2021.118772.
APA：
Huang Chunfan,Jing Xiaoqi,Wu Qianhu&Ding Kan.(2022).Novel pectin-like polysaccharide from Panax notoginseng attenuates renal tubular cells fibrogenesis induced by TGF-β..Carbohydrate polymers,276,
MLA：
Huang Chunfan,et al."Novel pectin-like polysaccharide from Panax notoginseng attenuates renal tubular cells fibrogenesis induced by TGF-β.".Carbohydrate polymers 276.(2022):118772

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